Achilles Tendon Pain Clinical Trial
— APBOfficial title:
Impact of Peripheral Pain Perception on Central Sensitization and Movement Strategies in Patients With Chronic Achilles Tendinopathy
Verified date | July 2019 |
Source | University of Iowa |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT). These findings will motivate the development of future clinical studies that incorporate knowledge about pain processing and movement strategies in patients with tendinopathy. Participants with achilles tendinopathy will receive an anesthetic injection to the achilles tendon in order to examine how reduced pain, detected by the peripheral nervous system, alters task performance and perception of pain. We hypothesize that there are factors within the central nervous system that contribute to continued pain and disability in patients with chronic AT.
Status | Completed |
Enrollment | 46 |
Est. completion date | May 10, 2018 |
Est. primary completion date | May 10, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility |
For patients with AT Inclusion Criteria: - Clinical diagnosis of chronic (>3 months) AT, consisting of pain with pressure at the achilles tendon and report of pain that is aggravated by physical activity Exclusion Criteria: - History of foot or ankle surgery, bilateral lateral epicondyle tendinopathy - Comorbidity that would be aggravated by placing hand in water (Raynaud's, thoracic outlet syndrome) - Comorbidity (e.g. stroke, neurological disorder) that limits ability to participate in exercise - Comorbidity (e.g. rheumatic disease, fibromyalgia) that contributes to pain with activity - Peripheral neuropathy - Previous adverse response to a local anesthetic injection - Are pregnant - Are a ballroom dancer For control participants Inclusion Criteria: - Sex, Age and BMI-matched to participant with AT Exclusion Criteria: - No history of tendinopathy - No condition that limited activity in the past 6 months - History of foot or ankle surgery, bilateral lateral epicondyle tendinopathy - Comorbidity that would be aggravated by placing hand in water (Raynaud's, thoracic outlet syndrome) - Comorbidity (e.g. stroke, neurological disorder) that limits ability to participate in exercise - Comorbidity (e.g. rheumatic disease, fibromyalgia) that contributes to pain with activity - Peripheral neuropathy - Are pregnant - Are a ballroom dancer |
Country | Name | City | State |
---|---|---|---|
United States | University of Iowa | Iowa City | Iowa |
Lead Sponsor | Collaborator |
---|---|
Ruth Chimenti |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Central Sensitization | Pressure pain threshold (PPT) at heel on contralateral side. A pressure algometer (Somedic, Farsta, Sweden) was applied perpendicular to the skin at a rate of 50 kilopascal/s with a 1cm2 tip. The participants pressed a button when the sensation of pressure first became painful (1/10 on NPRS). The mean of 3 trials per area represented the PPT. | Within session, baseline and 30 minutes after an anesthetic injection | |
Primary | Pain Psychology | Tampa Scale of Kinesiophobia (TSK, score range 17 to 68). A decrease in TSK would indicate a decrease in fear of injury (and/or re-injury) | Within session, baseline and 30 minutes after an anesthetic injection | |
Primary | Movement System | Change in peak ankle power during the stance phase of gait during stair ascent, which will be assessed by syncing movement data from 3-dimensional motion analysis with ground reaction force data from a force plate. Peak positive ankle power reflects the ability of the plantar flexor muscles to concentrically generate speed and force at the ankle joint. | Within session, baseline and 30 minutes after an anesthetic injection |
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