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Does Dapagliflozin Promote Favorable Health Benefits That Are Independent Of Weight Loss?

Weight Loss Clinical Trial

Official title:
Does Dapagliflozin Promote Favorable Health Benefits That Are Independent Of Weight Loss?

Clinical Trial Summary

Th mechanism of action of dapagliflozin is via sodium-glucose co-transporter 2 (SGLT2) inhibition. Sodium-glucose co-transporter 2 inhibition is associated with moderate weight (fat) loss, in addition to other health benefits, including decreased blood pressure, decreased inflammation, and decreased oxidative stress. It is unclear as to whether these health benefits are due to SGLT2 inhibition per se, or as a secondary effect of weight loss.

Clinical Trial Description

This is a randomized, prospective, placebo-controlled, double-blind, repeated measures study. 92 overweight/obese adults (body mas index > 27.5 kg/m^2) will be recruited for participation and randomly assigned to one of four 12 week treatments: 1) daily oral administration of dapagliflozin with ad-libitum dietary intake; 2) daily oral administration of dapagliflozin with supplemented dietary intake to achieve weight maintenance; 3) daily oral administration of a placebo plus dietary restriction such that weight loss is matched to participants in treatment 1; or, 4) daily oral administration of a placebo with ad-libitum dietary intake. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02520518
Study type Interventional
Source Colorado State University
Contact
Status Terminated
Phase Phase 2
Start date August 2015
Completion date May 2017
View Details
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