Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

Weight-Lifting Exercise Program Clinical Trial

Official title:

Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02842593
• Other study ID #: REB 14-333-1
• Status: Completed
• Phase: N/A
• First received: July 15, 2016
• Last updated: January 13, 2017
• Start date: September 2014
• Est. completion date: August 2016

Study information

• Verified date: January 2017
• Source: McMaster University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: August 2016
• Est. primary completion date: August 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Male

• Aged 18-30 years old

• Non-obese (Body mass index less than 30 kg/m2)

• Non-smoker

• Healthy based on questionnaire responses

• Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion Criteria:

• Allergies to milk proteins (whey or casein)

• Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires

• Arthritic conditions

• Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded

• A history of neuromuscular problems

• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Related Conditions & MeSH terms

• Weight-Lifting Exercise Program

Intervention

Behavioral:
• Lower-repetition, heavier-load
8-12 reps/set at ~80% 1 repetition maximum
• Higher-repetition, lighter-load
20-25 reps/set at ~30% 1 repetition maximum

Locations

Country	Name	City	State
Canada	McMaster University	Hamilton	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
McMaster University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Carotid-femoral pulse wave velocity	Assessed using applanation tonometry	12 weeks post exercise training
Secondary	Common carotid artery distensibility	Assessed using vascular ultrasound	12 weeks post exercise training
Secondary	Left ventricular mass	Assessed using standard echocardiography	12 weeks post exercise training