VITAMIN D Disorders Clinical Trial
Official title:
Serum Vitamin D Level in Subfertile Women and Its Association With Ovarian Reserve and IVF Outcome.
Vitamin D has a major play in bone and calcium metabolism. Vitamin D deficiency (below 20
ng/ml) has also been linked to adverse health outcomes such as malignancy, cardiovascular
disease, immune functioning, and glucose metabolism. Recent data from retrospective and
prospective trials have demonstrated contradictive results concerning the role of vitamin D
in female reproduction and IVF outcome. Some studies have found that women deficient in
vitamin D had lower ovarian reserve and significantly lower clinical pregnancy rates when
compared to patients who were sufficient levels in vitamin D. Some studies also demonstrated
that serum 25-OH-D3 levels correlates with antimullerian hormone (AMH) levels in women of
advanced reproductive age. It may also have a role to play in endocrine dysfunction and
abnormal folliculogenesis in polycystic ovaries .
The aim of this prospective cohort study including infertile women undergoing IVF treatment
is to investigate the association between serum 25-OH- D3 levels and parametres of ovarian
reserve (AMH, antral follicle count, number of oocytes collected) and clinical pregnancy and
miscarriage rates .
Vitamin D has a major play in bone and calcium metabolism. Vitamin D deficiency (below 20
ng/ml) has also been linked to adverse health outcomes such as malignancy, cardiovascular
disease, immune functioning, and glucose metabolism. Recent data from retrospective and
prospective trials have demonstrated contradictive results concerning the role of vitamin D
in female reproduction and IVF outcome. Some studies have found that women deficient in
vitamin D had lower ovarian reserve and significantly lower clinical pregnancy rates when
compared to patients who were sufficient levels in vitamin D. Some studies also demonstrated
that serum 25-OH-D3 levels correlates with antimullerian hormone (AMH) levels in women of
advanced reproductive age. It may also have a role to play in endocrine dysfunction and
abnormal folliculogenesis in polycystic ovaries .
The aim of this prospective cohort study including infertile women undergoing IVF treatment
is to investigate the association between serum 25-OH- D3 levels and parametres of ovarian
reserve (AMH, antral follicle count, number of oocytes collected) and clinical pregnancy and
miscarriage rates .
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Observational Model: Cohort, Time Perspective: Prospective