Valvular Heart Disease Clinical Trial
Hyperlactatemia, occuring 10-20% in patients undergoing valvular heart surgery, is known to be associated with hemodynamic instability, organ dysfunction and increased postoperative morbidity and mortality. Glucose-Insulin-Potassium(GIK) has been constantly used as an adjuvant therapy in patients with myocardial infarction or in the patients undergoing valvular heart surgery to reduce the low cardiac output syndrome and mortality. GIK is known to prevent excretion of lactate and to increase the extraction of lactate after reperfusion with various mechanism. In addition, it is also known to decrease ischemic-reperfusion injury of myocardium after CPB, to improve myocardial contractility, insulin resistance and hyperglucemia. As a result, it brings hemodynamic stability and sufficient oxygen supply to the tissue, which might reduce the incidence of hyperlactatemia after valvular heart surgery.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Completed |
NCT02241109 -
Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity
|
N/A | |
| Completed |
NCT03799133 -
Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery
|
N/A | |
| Completed |
NCT01676727 -
ADVANCE Direct Aortic Study
|
||
| Completed |
NCT01476995 -
Prognostic Indicators as Provided by the EPIC ClearView
|
N/A | |
| Completed |
NCT00721136 -
Randomized Study of the Use of Warfarin During Pacemaker or ICD Implantation in Patients Requiring Long Term Anticoagulation
|
N/A | |
| Recruiting |
NCT05044338 -
Study on Standard Evaluation System and Optimal Treatment Path of Senile Valvular Heart Disease
|
||
| Recruiting |
NCT05014750 -
Frailty of Elderly With Valvular Heart Disease and the Short Term Adverse Events
|
||
| Recruiting |
NCT05015829 -
Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis
|
||
| Recruiting |
NCT05078619 -
Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation
|
N/A | |
| Recruiting |
NCT06307262 -
European Registry of Transcatheter Repair for Tricuspid Regurgitation
|
||
| Completed |
NCT01624870 -
CoreValve Advance-II Study: Prospective International Post-market Study
|
||
| Completed |
NCT05708690 -
Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery
|
Phase 4 | |
| Recruiting |
NCT03797820 -
Multicenter Registry Study of Aortic Valve Stenosis in Zhejiang Elderly（Mrs AVS）
|
||
| Recruiting |
NCT06077721 -
Milrinone on Right Ventricular Strain in Cardiac Surgery
|
||
| Not yet recruiting |
NCT04632914 -
Effect of Trunk Stabilizing Exercises on Patients With Median Sternotomy After Heart Valve Surgery
|
N/A | |
| Completed |
NCT01477151 -
Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery
|
Phase 4 | |
| Terminated |
NCT03590730 -
Benefits of ICD for the Primary Prevention in Patients With Valvular Cardiomyopathy
|
||
| Recruiting |
NCT06204783 -
Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardiovascular Physiology During Therapeutic Strategies Aiming for Hemodynamic Optimization. Cohort II: Structural Heart Interventions (PLUTO-II)
|
||
| Enrolling by invitation |
NCT05775354 -
Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project
|
N/A |