Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery

Status Completed

Clinical Trial Summary

The purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different sevoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE)in cardiac surgery patients.

Clinical Trial Description

Following data would be determined after 10 min-exposure to each dosage of sevoflurane with 1.0, 2.0 and 3.0 inspired vol% (T1, T2 and T3, respectively) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=14):

1. TDI of lateral mitral annulus at systole (S'), early filling (E') and atrial contraction (A')

2. transmitral flow Doppler at early filling (E), atrial contraction (A), deceleration time;

3. LV-ejection fraction (EF)

4. bispectral index (BIS)

5. phenylephrine-infusion rate

6. other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), mixed venous O2 saturation (SvO2), cardiac index (CI) and stroke volume index (SVI) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01511991
Study type	Interventional
Source	Konkuk University Medical Center
Contact
Status	Completed
Phase	Early Phase 1
Start date	May 2009
Completion date	May 2014

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