Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PRA-027 in Japanese Postmenopausal Women

Uterine Leiomyomata (Fibroids) Clinical Trial

Official title:

A Randomized, Placebo-Controlled, Double-Blind, Multiple-Dose Study of the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of PRA-027 Administered Orally to Japanese Postmenopausal Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00826436
• Other study ID #: 3208A1-1008
• Status: Completed
• Phase: N/A
• First received: January 20, 2009
• Last updated: March 5, 2009
• Start date: November 2008
• Est. completion date: March 2009

Study information

• Verified date: March 2009
• Source: Wyeth is now a wholly owned subsidiary of Pfizer
• Contact: n/a
• Is FDA regulated: No
• Health authority: Japan: Ministry of Health, Labor and Welfare
• Study type: Observational

Clinical Trial Summary

The primary purpose of this study is to assess the safety and tolerability of ascending, multiple, oral doses of PRA-027 in Japanese postmenopausal women. The secondary purpose is to evaluate the PK and PD profile of multiple oral doses of PRA-027 in Japanese postmenopausal women.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: March 2009
• Est. primary completion date: March 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 35 Years to 65 Years

Eligibility

INCLUSION CRITERIA:

1. Aged 35 to 65 years inclusive on study day 1 of the treatment period. Menopause may be spontaneous or due to surgery.

Postmenopausal women are defined as follows:

• Spontaneous amenorrhea must have begun by age 55 years.

• Spontaneous amenorrhea must have initiated at least 6 months before study day 1 of the treatment period.

• For subjects who have had spontaneous amenorrhea for at least 6 months but less than 12 months before screening, follicle-stimulating hormone (FSH) level must be = 38 mIU/mL.

• For subjects who have had spontaneous amenorrhea for 12 months or longer before screening, no FSH level determination is required.

• For subjects who have had amenorrhea as a result of bilateral oophorectomy without hysterectomy; surgery must have occurred at least 6 months before screening. No FSH measurement is required. Subjects must provide evidence of the procedure by an operative report or by ultrasound scan. The date (month/year) of the subjects' last menstrual period must be determined and recorded on the source document.

2. Body mass index (BMI) in the range of 17.6 to 26.4 kg/m2 and bodyweight = 45 kg.

BMI is calculated by taking the subject's weight, in kilograms, divided by the square of the subject's average height, in meters, at screening:BMI = weight (kg)/[Height (m)]2

3. Healthy, as determined by the investigator, on the basis of screening evaluations.

4. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine levels should be below the upper limit of normal at screening.

5. Nonsmoker or smoker of fewer than 10 cigarettes per day as determined by history. Must be able to abstain from smoking during the inpatient stay.

6. Have a high probability for compliance with and completion of the study.

EXCLUSION CRITERIA:

1. Presence or history of any disorder that may prevent the successful completion of the study.

2. Any significant cardiovascular, hepatic, renal, respiratory,gynecologic, gastrointestinal, endocrine, immunologic,dermatologic, hematologic, neurologic, or psychiatric disease.

• Women with asymptomatic leiomyomata may be enrolled in the study.

3. Women who have undergone a hysterectomy.

4. Women with complex or simple ovarian cysts greater than 3 cm indiameter.

5. Any surgical or medical condition that may interfere with the absorption, distribution, metabolism, or excretion of the test article (eg, resection of liver, kidney, gallbladder, or gastrointestinal tract).

6. Acute disease state (eg, nausea, vomiting, fever, or diarrhea) within 7 days before receiving test article (treatment period study day 1).

7. History of drug abuse.

8. Admitted alcohol abuse or history of alcohol use that may interfere with the subject's ability to comply with the protocol requirements.

9. History or presence of polycystic ovarian disease.

10. History of female infertility.

11. History or family history of arterial or venous thrombosis.

12. Any clinically significant deviation from normal limits in results of physical examinations, vital sign measurements, 12-lead electrocardiograms (ECGs), or clinical laboratory tests.

13. Demonstration of positive findings on orthostatic testing at screening. The definition of a positive finding is a =20 mm Hg decrease in systolic blood pressure, a = 10 mm Hg decrease in diastolic blood pressure, or a = 30 bpm increase in pulse, after standing for 3 minutes.

14. Positive serologic findings for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen (HBsAg), and/or hepatitis C virus (HCV) antibodies.

15. Positive findings from urine drug screening (eg, amphetamines,barbiturates, benzodiazepines, cannabinoids, cocaine, opiates and phencyclidine [PCP]).

16. History of any clinically important drug allergy or adverse drug reaction (eg, relapsing dermatitis, drug hypersensitivity, drug allergy, hypersensitivity to ingredient in the test articles, angioedemas)

17. Use of any investigational or prescription drug within 90 days before receiving test article (treatment period day 1)or prescription drug within 30 days before study day 1.

18. Consumption of any caffeine-containing products (eg, coffee, tea, chocolate, or carbonated beverages) or alcoholic beverages within 48 hours before receiving test article (treatment period day 1).

19. Consumption of grapefruit or grapefruit-containing products within 72 hours before study day 1 (treatment period day 1).

20. Use of any over-the-counter drugs, including herbal supplements (except for the use of vitamins = 100% of the recommended daily allowance), within 14 days before receiving test article (treatment period day 1).

21. Donation of blood within 90 days before study day 1.

22. Subjects deemed by the investigator to be inappropriate according for the inclusion in the study.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Leiomyoma
• Uterine Leiomyomata (Fibroids)

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Wyeth is now a wholly owned subsidiary of Pfizer

Country where clinical trial is conducted

Japan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To assess the safety and tolerability of multiple oral doses of PRA-027 in postmenopausal women.		28 days	Yes
Secondary	To evaluate the Pharmacokinetics and Pharmacodynamics profile of multiple oral doses of PRA-027 in postmenopausal women.		28 days	No