The Treatment Effect of Chinese Medicine Formula on Uremic Pruritus

Status Not yet recruiting

Clinical Trial Summary

Clinical Trial Description

The prevalence of hemodialysis patients is increasing in recent years. And the uremic pruritus is a common and bothersome symptom among the patients. Current therapies for uremic pruritus, including dialysis modification, topical treatment such as emollients and topical analgesic agent, phototherapy, acupuncture, and gabapentin. However, the efficacy of these treatments remains poorly defined. In our experiment, the investigators tried to find an effective way to control uremic pruritus through Chinese traditional medicine. "Xiao-Feng-San" is a common Chinese herbal preparation, composed of 13 herbs, which is used to treat patients with dermatitis. The component of "Xiao-Feng-San" has immunomodulatory activity. "Shian Fang Hwa Ming Yiin" is another common Chinese herbal preparation, composed of 12 herbs, which is used to treat patients with carbuncles and acne. The component of "Shian Fang Hwa Ming Yiin" has anti-inflammation and anti-microbial effect. The purpose of this study is to evaluate the treatment effect of Xiao-Feng-San and Shian Fang Hwa Ming Yiin on uremic pruritus among hemodialysis patients in this randomized, double-blind, placebo-controlled study design. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04650750
Study type	Interventional
Source	Chang Gung Memorial Hospital
Contact	Jiun-Liang Chen, Ph.D
Phone	+88633196200
Email	a12015@adm.cgmh.org.tw
Status	Not yet recruiting
Phase	Early Phase 1
Start date	December 1, 2020
Completion date	December 31, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04728984` - A Multi-site Bridging Study of Nalfurafine Hydrochloride Orally Disintegrating Tablet	Phase 3
Completed	`NCT02143973` - Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus	Phase 2/Phase 3
Terminated	`NCT01660243` - Efficacy and Safety of MT-9938 for Treatment of Uremic Pruritus in Subjects With End-stage Renal Disease Receiving Hemodialysis	Phase 2
Completed	`NCT06159686` - The Efficacy of Hemp-containing Cream Versus Placebo in the Treatment of Uremic Pruritus	Phase 1/Phase 2
Not yet recruiting	`NCT05525234` - A Study of Thalidomide in the Treatment of Refractory Uremic Pruritus	Phase 4
Completed	`NCT03002233` - TRK-820 Study in Subjects on Hemodialysis With or Without Uremic Pruritus	Phase 1
Completed	`NCT03998163` - CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus	Phase 3
Active, not recruiting	`NCT05885737` - Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus	Phase 3
Recruiting	`NCT04393675` - Study to Investigate the Safety of LT5001 Drug Product for Uremic Pruritus in Hemodialysis Patients	Phase 1/Phase 2
Completed	`NCT03576235` - Safety and Efficacy of PG102P for Uremic Pruritus in HD Patients	N/A
Completed	`NCT05575193` - Acupressure on Uremic Pruritus and Sleep Quality Among Patients Receiving Hemodialysis	N/A
Completed	`NCT02858726` - Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus	Phase 2/Phase 3
Completed	`NCT02143648` - Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus	Phase 2/Phase 3
Completed	`NCT00494975` - The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease	N/A
Completed	`NCT03758079` - Comparison of Gabapentin With Doxepin in the Management of Uremic Pruritus	Phase 4
Completed	`NCT02229929` - Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pruritus	Phase 2
Completed	`NCT04639674` - AST-120 in Hemodialysis Patients With Uremic Pruritus	Phase 4
Completed	`NCT03636269` - CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus	Phase 3
Completed	`NCT04711603` - A Phase III Clinical Study of MR13A9 in Hemodialysis Patients With Pruritus.	Phase 3
Completed	`NCT02696499` - Treatment of Uremic Pruritus With PA101B	Phase 2