HIT in People With Type 1 Diabetes

Type1diabetes Clinical Trial

Official title:

High-Intensity Interval Training Improves Aerobic Capacity and Abolishes the Decline in Blood Glucose Observed During Moderate-Intensity Continuous Training Sessions in People With Type 1 Diabetes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03545841
• Other study ID #: T1D_PARTB
• Status: Completed
• Phase: N/A
• Start date: March 9, 2015
• Est. completion date: October 10, 2017

Study information

• Verified date: June 2018
• Source: Liverpool John Moores University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

Description:

This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: October 10, 2017
• Est. primary completion date: October 10, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• duration of type 1 diabetes >6 months

• basal bolus regimen

• no significant history of hyper- or hypoglycaemia (determined from medical history)

Exclusion Criteria:

duration of type 1 diabetes <6 months,

• insulin pump therapy

• significant history of hyper- or hypoglycaemia (determined from medical history)

• obesity (BMI >30 kg·m-2)

• pregnancy or planning pregnancy

• uncontrolled hypertension (>180/100 mmHg)

• angina, autonomic neuropathy

• taking any medication that affects heart rate

• major surgery planned within 6 weeks of the study

• severe nonproliferative

• unstable proliferative retinopathy

Related Conditions & MeSH terms

• Diabetes Mellitus
• Diabetes Mellitus, Type 1
• Type1diabetes

Intervention

Other:
• HIT
Participants completed 6 weeks of HIT
• MICT
Participants completed 6 weeks of MICT

Locations

Country	Name	City	State
United Kingdom	Liverpool John Moores University	Liverpool	Merseyside

Sponsors (1)

Lead Sponsor	Collaborator
Liverpool John Moores University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximal aerobic capacity	Maximal aerobic capacity test pre and post 6-week training intervention	change in baseline maximal aerobic capacity at 6 weeks
Secondary	Vascular stiffness	Aortic pulse wave velocity to measure vascular stiffness	change in baseline vascular stiffness at 6 weeks