Fasted Exercise in People With Type 1 Diabetes

Type1diabetes Clinical Trial

Official title:

Fasted High-Intensity Interval and Moderate-Intensity Continuous Exercise Are Not Associated With A Detrimental 24-Hour Blood Glucose Profile

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03544684
• Other study ID #: T1D_PARTA
• Status: Completed
• Phase: N/A
• Start date: March 9, 2015
• Est. completion date: October 10, 2017

Study information

• Verified date: June 2018
• Source: Liverpool John Moores University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Description:

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period. Fourteen people with type 1 diabetes (duration of type 1 diabetes 8.2±1.4 years), all on basal-bolus regimen, completed a randomised, counterbalanced, crossover study. Continuous glucose monitoring was used to assess glycaemic control following a single bout of HIT (6 x 1min intervals) and 30 mins of moderate-intensity continuous training (MICT) on separate days, compared to a non-exercise control day (CON). Exercise was undertaken following an overnight fast with omission of short-acting insulin. Capillary blood glucose samples were recorded pre and post-exercise to assess the acute changes in glycaemia during HIT and MICT.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: October 10, 2017
• Est. primary completion date: October 10, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• duration of type 1 diabetes >6 months

• basal bolus regimen

• no significant history of hyper- or hypoglycaemia (determined from medical history

Exclusion Criteria:

• duration of type 1 diabetes <6 months,

• insulin pump therapy

• significant history of hyper- or hypoglycaemia (determined from medical history)

• obesity (BMI >30 kg·m-2)

• pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg)

• angina

• autonomic neuropathy

• taking any medication that affects heart rate

• major surgery planned within 6 weeks of the study

• severe nonproliferative and

• unstable proliferative retinopathy

Related Conditions & MeSH terms

• Diabetes Mellitus, Type 1
• Type1diabetes

Intervention

Behavioral:
• Effects of the type of exercise on blood glucose concentrations
glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training

Locations

Country	Name	City	State
United Kingdom	Liverpool John Moores University	Liverpool	Merseyside

Sponsors (1)

Lead Sponsor	Collaborator
Liverpool John Moores University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	24 hour glycaemic profile	Continuous glucose monitoring will be used to assess the effects of an acute bout of fasted high intensity interval training or moderate intensity continuous training on 24 hour glycaemic profile.	24 hours