Type 1 Diabetes Mellitus Clinical Trial
Official title:
Prediction of Type 1 Diabetes: Molecular Quantification of Insulin mRNA in the While Cell Fraction of Whole Blood
The objectives of this study are to:
1. quantitate the level of insulin mRNA in the while cell fraction of whole blood in
selected groups of subjects,
2. determine the gene expression of markers of white cell activation in the white cell
fraction of whole blood in selected subjects,
3. determine the identity of the white cell responsible for expression of insulin mRNA and
4. determine protein expression of mRNA of insulin/proinsulin and selected genes of white
cell activation.
Indicators of active immune or chemically mediated beta cell destruction would be helpful
for predicting the development and severity of autoimmune diabetes and monitoring the
success of islet transplants. Currently there are no reliable indicators readily available.
Insulin mRNA in the white cell fraction of blood has been detected or elevated under several
circumstances including:
1. normal animals
2. after islet cell transplantation
3. hyperglycemic induced expression and
4. during induction of diabetes with streptozotocin
The investigators propose that quantitative measurement of insulin mRNA may be an accurate,
innovative and minimally invasive indicator of beta cell destruction.
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