Turner Syndrome Clinical Trial
Official title:
Growth Hormone Treatment of Women With Turner Syndrome: Body Composition and Heart Function.
Growth hormone treatment is used in girls with Turner syndrome to increase final height. The aim of this study is to evaluate the effect of growth hormone treatment on body composition and heart function in adult women with Turner syndrome. The hypothesis is that the fat mass will decrease and lean body mass will increase. There is only very limited documentation of the effect on the heart in this study population.
This study is a randomised, double-blinded, controlled clinical trial to evaluate the effect
of growth hormone (GH) treatment on adult women with Turner syndrome. The endpoints will be
changes in body composition and heart function evaluated by echocardiography (ECHO) and
positron emission tomography (PET).
Phase one: 6 months of GH or placebo treatment. Phase two: "open label" all participants are
treated with GH for 12 months. At baseline, healthy controls will be examined, but will not
receive any treatment
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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