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Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis

Tuberculosis, Pulmonary Clinical Trial

Official title:
Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis: A Randomized Controlled Trial

Clinical Trial Summary

This study was a randomized controlled trial studying about acid-fast bacillus sputum conversion ratio from positive to negative of pulmonary tuberculosis patients between metformin with pulmonary tuberculosis standard treatment group and placebo drug with pulmonary tuberculosis standard treatment.

Clinical Trial Description

1. Pulmonary tuberculosis Patients with presence of at least one acid-fast bacillus in the sputum will be examined by an internist. 2. Collect the necessary basic information of patients who agree to participate in the treatment such as complete blood count, blood urea nitrogen, creatinine, liver function test, fasting plasma glucose, hemoglobinA1C, lactate, and gene expression signature for tuberculosis. 3. Patients will be randomized into 2 groups: those who will receive metformin with pulmonary tuberculosis standard treatment and those who will receive placebo drug with pulmonary tuberculosis standard treatment. 4. Patients will get a chest x-ray and collect sputum acid fast bacillus, sputum culture for tuberculosis and collect blood sample laboratory such as complete blood count, liver function test, creatinine, fasting plasma glucose, lactate, and gene expression signature for tuberculosis at second week. 5. Patients will get a chest x-ray and collect sputum acid fast bacillus, and sputum culture for tuberculosis at second month. 6. Patients will get a chest x-ray and collect sputum acid fast bacillus, and sputum culture for tuberculosis at fifth month. 7. Patients will get a chest x-ray and collect sputum acid fast bacillus, and sputum culture for tuberculosis at sixth month. 8. After collecting all information of patients, Investigators will analyze in clinical and statistical analysis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05215990
Study type Interventional
Source Mahidol University
Contact Angsana Phuphuakrat, MD, PhD
Phone 6622011581
Email angsana.phu@mahidol.ac.th
Status Recruiting
Phase Phase 1/Phase 2
Start date January 15, 2022
Completion date March 31, 2023
View Details
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