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Brain Monitoring for High Risk of Brain Metastases in Metastatic Breast Cancer

Triple Negative Breast Cancer Clinical Trial

Official title:
Brain Monitoring for High Risk of Brain Metastases in Metastatic Breast Cancer

Clinical Trial Summary

In general, brain metastases found after development of neurologic symptoms have poor prognosis. Therefore, the investigators aim to investigate whether regular brain MRI (Magnetic Resonance Imaging) can detect early brain metastases and influence survival through early brain management in HER2-positive and triple negative breast cancer.

Clinical Trial Description

It is well known that HER2-receptor positive and triple negative metastatic breast cancer (MBC) have poor prognosis than hormone receptor positive metastatic breast cancer. However, as new therapies such as trastuzumab and pertuzumab are introduced, overall survival was extended in patients with metastatic breast cancer compared with the previous 10 years. As a result, the number of breast cancer patients with brain metastases has increased, the demand for treatments of brain metastases is increasing. The incidence of brain metastases in MBC has been reported to be 7.6% and 10.8% in luminal A / B, respectively. However, HER2-positive and triple negative breast cancer with the incidence of more than 30% of brain metastases were at high risk group of brain metastases. In general, brain metastases found after development of neurologic symptoms have poor prognosis. Therefore, the investigators aim to investigate whether regular brain MRI (Magnetic Resonance Imaging) can detect early brain metastases and influence survival through early brain management in HER2-positive and triple negative breast cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03617341
Study type Observational
Source Yonsei University
Contact Joohyuk Sohn, MD, Ph.D
Phone 82-2-2228-8130
Email oncosohn@yuhs.ac
Status Recruiting
Phase
Start date October 2, 2018
Completion date June 3, 2023
View Details
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