Trauma Clinical Trial - Massive Transfusion in Trauma Patient Registry

Status Recruiting

Clinical Trial Summary

The early use of blood products as a part of Massive Transfusion Protocol (MTP) during trauma resuscitation has been increasingly supported by providers and backed by the literature. However, the incidence of hypocalcemia during MTP has also been recorded and continues to be studied as an exacerbating factor in coagulopathy during trauma.

Clinical Trial Description

Although initially it was thought that the coagulopathy was due to the trauma itself, studies suggest that it is worsened by the transfusion of blood as this is associated with increased hypocalcemia. The level of hypocalcemia is said to correlate with the amount of blood products transfused, but the number of units needed to produce a particular degree of hypocalcemia remains to be defined. A standardized value for hypocalcemia due to MTP has yet to be established. Establishing this value would be helpful in determining what level actually affects the rate of mortality. Some studies suggest intravenous calcium supplement should be considered during massive transfusion while others state this does not make a difference. This data repository will serve as a means to aggregate and analyze best practices as relative to MTP in the trauma patient, with specific interest in component best practices, whole blood protocols, and electrolyte/metabolite replacement. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06136715
Study type	Observational
Source	Methodist Health System
Contact	Bethany Brauer, MPH
Phone	214-947-4681
Email	MHSIRB@mhd.com
Status	Recruiting
Phase
Start date	July 13, 2023
Completion date	July 13, 2025

View Details

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