Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules

Status Completed

Clinical Trial Summary

Use of ethanol injection in treatment of cystic thyroid nodule

Clinical Trial Description

Thyroid nodules are common discreet lesions in the parenchyma of thyroid gland which can either be palpated or made out during imaging like ultrasonography (USG).Clinically palpable thyroid nodules have a prevalence of 4-7% in the general population . However, the prevalence increases to 20-76% when USG is used for detection.

Goiter and the associated thyroid nodules result in anxiety, cosmetic disfigurement, and rarely compressive symptoms necessitating surgical removal, a procedure inherently associated with risks and complications Percutaneous sclerotherapy has been suggested to be an effective alternative, especially in patients with cystic nodules. Simple cystic (purely cystic) constitutes 6-28% of all thyroid nodules, are usually benign, filled with cellular debris or blood, and are a result of degeneration or hemorrhage into a hyperplastic nodule.

Among the various compounds (sodium tetradocyl sulfate, hydroxypolyethoxydodecan, tetracycline, and ethanol) tried for sclerosis of cystic thyroid nodules, outcomes are best and most studied with ethanol. However, data on outcomes of percutaneous aspiration and ethanol injection (PEI) in resolution of thyroid nodules is highly variable in different studies (success rate: 38-85%), which may be due to different populations studied and the heterogeneous nature of thyroid nodules evaluated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03257930
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	Phase 1
Start date	August 11, 2017
Completion date	January 1, 2019

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04614389` - Utility of Contrast-Enhanced Sonography and Shear Wave Elastography	N/A
Recruiting	`NCT03295955` - Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy	N/A
Completed	`NCT04647006` - Comparison of TOETVA and Conventional Thyroidectomy	N/A
Not yet recruiting	`NCT06029946` - B-mode Ultrasound, Sono-Elastography, and Diffusion-weighted Imaging MRI in Thyroid Nodules
Recruiting	`NCT05025046` - NGS-based Thyroscan Genomic Classifier in the Diagnosis of Thyroid Nodules
Terminated	`NCT01320813` - Trial Comparing Complication Rates Associated With Robot-assisted Thyroidectomy to External Thyroidectomy	N/A
Completed	`NCT00877630` - Minimal Invasiveness of Endoscopic Thyroidectomy	N/A
Completed	`NCT01964508` - microRNA in Thyroid Cancer
Completed	`NCT06306599` - Ultrasound Operator Influence on Diagnostics With AI for Thyroid Nodules - Clinial Trial	N/A
Recruiting	`NCT04730726` - In Vivo Multispectral Optoacoustic Imaging of Thyroid Nodules	N/A
Not yet recruiting	`NCT03884140` - Clinical Diagnostic Approach for Cases of Thyroid Nodules
Completed	`NCT04277455` - Effect of Ultrasound Guided Laser Ablation Therapy on Symptomatic Benign Thyroid Nodules	N/A
Recruiting	`NCT02225509` - Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology	N/A
Completed	`NCT00552253` - Levothyroxine Treatment in Thyroid Benign Nodular Goiter	N/A
Not yet recruiting	`NCT03700762` - Application of Ultrasonic Gray-scale Ratio in Differentiating Benign From Malignant Thyroid Nodules.
Enrolling by invitation	`NCT01757834` - Shear Wave Ultrasound Elastography in Noninvasive Diagnosis of Thyroid Nodules	N/A
Completed	`NCT01292044` - The Role of Elastography in the Diagnosis of Thyroid Nodules	N/A
Completed	`NCT00858104` - Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results	Phase 4
Completed	`NCT00651625` - Reciprocating Medical Devices - a Study of a New Safety Device	N/A
Completed	`NCT05132478` - The Effect of Surgeon Emotional Support on Treatment Choice for Low-risk Thyroid Cancer	N/A