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Tachycardia, Ventricular clinical trials

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NCT ID: NCT04127643 Recruiting - Heart Failure Clinical Trials

Prospective Clinical Registry of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) (S-ICD Korea Registry)

Start date: May 10, 2019
Phase:
Study type: Observational

S-ICD avoids the use intravascular leads and their associated risks, has been increasingly used for primary and secondary prevention of sudden death. The long-term safety and feasible of S-ICD system in Asian population with a smaller body size remain unclear. The investigators propose to perform a prospective study in Korean population to investigate the safety and feasibility of S-ICD for primary or secondary prevention of sudden cardiac death.

NCT ID: NCT04066517 Recruiting - Clinical trials for Refractory Ventricular Tachycardia

STereotactic RadioAblation by Multimodal Imaging for VT (STRA-MI-VT)

STRA-MI-VT
Start date: September 13, 2019
Phase: N/A
Study type: Interventional

Study of multimodal-imaging guided stereotactic body radiotherapy (SBRT) for ventricular tachycardia (VT) ablation.

NCT ID: NCT04065802 Recruiting - Clinical trials for Stereotactic Radioablation for Ventricular Tachycardia

Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia Management

STAR VTM
Start date: April 14, 2021
Phase: N/A
Study type: Interventional

Stereotactic Arrhythmia Radioablation (STAR) ablation is a safe and feasible option for cardiomyopathy patients for management of refractory ventricular tachycardia. STAR can be performed with available cardiac imaging, prior mapping/electrogram information, and standard ECGs without a multi-electrode ECG vest.

NCT ID: NCT03870854 Recruiting - Clinical trials for Ischemic Ventricular Tachycardia (VT)

Paced Electrogram Feature Analysis (PEFA) for Ablation Targeting in Ischaemic Ventricular Tachycardia

PEFA-VT
Start date: August 13, 2019
Phase: N/A
Study type: Interventional

Canadian multicentre prospective cohort study of 40 patients with ischaemic heart disease and therapy from an implantable cardioverter defibrillator (ICD).

NCT ID: NCT03855826 Recruiting - Clinical trials for Ventricular Tachycardia

Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection.

Start date: January 15, 2019
Phase: Phase 4
Study type: Interventional

Efficacy and safety evaluation of amiodarone and Nifekalant hydrochloride(NIF) for the treatment of ventricular tachycardia and ventricular fibrillation.

NCT ID: NCT03853369 Recruiting - Clinical trials for Ventricular Tachycardia

Post-marketing Registration Study of Nifekalant Hydrochloride (NIF) Injection

Start date: February 18, 2019
Phase:
Study type: Observational

Retrospective and Prospective single arm, observational study to evaluate efficacy and safety of NIF in the treatment of ventricular tachycardia and ventricular fibrillation. The information registration of the target population will be collected with the hospital HIS system or LIS system.

NCT ID: NCT03833089 Recruiting - Atrial Fibrillation Clinical Trials

Targeted Potassium Levels for Prevention of ICD Therapy

Start date: April 1, 2019
Phase: Phase 4
Study type: Interventional

This study evaluates whether a rigorously controlled high-normal level of serum-potassium (4.5-5.0 mEq/L) using dietary recommendations, potassium supplements and mineralocorticoid receptor antagonists will results in a lower incidence of cardiac arrhythmias in patients with an ICD. Patients will be randomized to this treatment or a control arm, where patients will receive usual guideline recommended follow-up.

NCT ID: NCT03826524 Recruiting - Clinical trials for Ventricular Fibrillation

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

EpiDOSE
Start date: May 24, 2023
Phase: Phase 4
Study type: Interventional

The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.

NCT ID: NCT03816033 Recruiting - Atrial Fibrillation Clinical Trials

Cryotherapy Versus Radiofrequency Catheter Ablation Research Program

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

A program of research has been set up at St. George's Hospital, London studyng the practicalities of catheter ablation. The current practice of catheter ablation is being studied for a range of arrhythmias including PAF, persistent AF, advanced persistent AF and resistant WPW.

NCT ID: NCT03713866 Recruiting - Clinical trials for Myocardial Infarction

Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia

ECGI-VT
Start date: November 1, 2019
Phase: N/A
Study type: Interventional

Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar. An important treatment is to use catheter ablation to "block" the channel that forms the circuit. Effective ablation requires imaging guidance to visualize the VT circuit relative to scar structures in 3D. Unfortunately, with conventional catheter mapping, up to 90% of the VT circuits are too short-lived to be mapped. For the 10% "mappable" VTs, their data are only available during ablation and limited to one ventricular surface. This inadequacy of functional VT data largely limits the knowledge about scar-related VT and ablation strategies, and reduces the ability of clinicians to identify ablation targets and assess ablation outcome. The central hypothesis of this proposal is that functional VT data, integrated with CT or MRI scar data in 3D, can improve VT ablation efficacy with pre-procedural identification of ablation targets and post-procedural mechanistic elucidation of ablation failure. This research builds on the rapidly increasing clinical interest in electrocardiographic imaging (ECGi), an emerging technique that obtains cardiac electrical activity through inverse reconstructions from ECGs. The specific objective is to push the boundary of ECGi to provide - as a conjunction to intra-procedural catheter mapping - pre-ablation and post-ablation imaging of functional VT circuits integrated with 3D scar structure.