Systemic Lupus Erythematosus Clinical Trial
In daily clinical use, pulse high dosis corticosteroids are used to treat cerebral edema in
different pathological situations ( surgery, trauma, tumors...). Dehydration can theorically
concern extra-cellular or intracellular water, or both.
The relative proportion of those two components are not known, as well their kinetics.
Diffusion Weighted Imaging ( DWI) is a none invasive and none toxic technique to study those
phenomena.We can also study the diffusivity anisotropy not using a Gaussian distribution but
rather a non- gaussian one, more close to the reality ( q Space Imaging ).
Finally, we can study the compartment redistribution between slow and rapid water molecules
diffusion by bi-exponential decomposition of the diffusion signal, corresponding,
theorically, respectively to the intra- and extra-cellular component.
Hypothesis : The high dosis steroid pulse therapy modifies or not the water free diffusion
in DWI and qSI ? Is there a modification in the diffusivity of both rapid and slow component
?
n/a
Observational Model: Defined Population, Time Perspective: Longitudinal
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