Coronary Artery Disease Clinical Trial
Official title:
Preoperative Oral Magnesium Versus Standard of Care to Prevent Postoperative Atrial Fibrillation Following Coronary Surgery (POMAF-CS): A Randomized Controlled Trial
Post operative atrial fibrillation following coronary surgery (POAF) is a common complication
that can affect 10-50% of patients.
Intravenous magnesium, administered per-or post-operatively, reduces the incidence of POAF.
However, the effect of preoperative magnesium loading on the incidence of POAF is not yet
studied.
200 patients admitted for elective coronary surgery under Cardiopulmonary bypass will be
included in this prospective randomized controlled trial.
Treatment group will receive preoperative oral magnesium and control group will receive
placebo for 3 days before the planned coronary artery surgery.
The occurrence of POAF will be studied as a main outcome.
Post operative atrial fibrillation following coronary surgery (POAF) is a common complication
that can affect 10-50% of patients. It is associated with many complications. POAF increases
the postoperative length of stay and increases the cost of hospitalization.
Several studies and meta-analyzes have demonstrated the beneficial effect of intravenous
magnesium (Mg), administered per-or post-operatively, in reducing the incidence of POAF.
However, the effect of preoperative magnesium loading on the incidence of POAF is not yet
studied.
The aim of this study is to study the effect of oral Mg, administered preoperatively, on the
incidence of POAF.
Following IRB approval, 200 patients admitted for elective coronary surgery under
Cardiopulmonary bypass will be included in this prospective randomized controlled trial.
Patients will be allocated inn a 1: 1 ratio in 2 groups:
- Treatment group will receive preoperatively 8 tablets of Mg (3.2 g) per day, at day
(-3), day (-2), and day (-1) before the day of planned coronary artery surgery.
- Control group will receive 8 tablets of placebo daily,at day (-3), day (-2), and day
(-1) before the day of planned coronary artery surgery.
The anesthetic and surgical management protocols will be identical for both groups. The
occurrence of POAF during the 7 postoperative days, the main outcome of the study, will be
recorded, including the number of POAF episodes, their duration, recurrence, and the
associated ventricular response rate. From a safety point, the occurrence of complications
and the length of hospital stay will be noted.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06030596 -
SPECT Myocardial Blood Flow Quantification for Diagnosis of Ischemic Heart Disease Determined by Fraction Flow Reserve
|
||
| Completed |
NCT04080700 -
Korean Prospective Registry for Evaluating the Safety and Efficacy of Distal Radial Approach (KODRA)
|
||
| Recruiting |
NCT03810599 -
Patient-reported Outcomes in the Bergen Early Cardiac Rehabilitation Study
|
N/A | |
| Recruiting |
NCT06002932 -
Comparison of PROVISIONal 1-stent Strategy With DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
|
N/A | |
| Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
| Recruiting |
NCT05308719 -
Nasal Oxygen Therapy After Cardiac Surgery
|
N/A | |
| Recruiting |
NCT04242134 -
Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions
|
N/A | |
| Completed |
NCT04556994 -
Phase 1 Cardiac Rehabilitation With and Without Lower Limb Paddling Effects in Post CABG Patients.
|
N/A | |
| Recruiting |
NCT05846893 -
Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease
|
N/A | |
| Recruiting |
NCT06027788 -
CTSN Embolic Protection Trial
|
N/A | |
| Recruiting |
NCT05023629 -
STunning After Balloon Occlusion
|
N/A | |
| Completed |
NCT04941560 -
Assessing the Association Between Multi-dimension Facial Characteristics and Coronary Artery Diseases
|
||
| Completed |
NCT04006288 -
Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease
|
Phase 4 | |
| Completed |
NCT01860274 -
Meshed Vein Graft Patency Trial - VEST
|
N/A | |
| Recruiting |
NCT06174090 -
The Effect of Video Education on Pain, Anxiety and Knowledge Levels of Coronary Bypass Graft Surgery Patients
|
N/A | |
| Terminated |
NCT03959072 -
Cardiac Cath Lab Staff Radiation Exposure
|
||
| Completed |
NCT03968809 -
Role of Cardioflux in Predicting Coronary Artery Disease (CAD) Outcomes
|
||
| Recruiting |
NCT04566497 -
Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.
|
N/A | |
| Recruiting |
NCT05065073 -
Iso-Osmolar vs. Low-Osmolar Contrast Agents for Optical Coherence Tomography
|
Phase 4 | |
| Completed |
NCT05096442 -
Compare the Safety and Efficacy of Genoss® DCB and SeQuent® Please NEO in Coronary De Novo Lesions
|
N/A |