Bio-Repository of DNA in Stroke: an Epidemiological and Genetic Study

Stroke Clinical Trial

— BRAINS  

Official title:

Bio-Repository of DNA in Stroke: an Epidemiological and Genetic Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05491824
• Other study ID #: BRAINS
• Status: Recruiting
• Start date: June 11, 2005
• Est. completion date: December 31, 2023

Study information

• Verified date: August 2022
• Source: Royal Holloway University
• Contact: Pankaj Sharma, MD PhD
• Phone: 01784434455
• Email: Pankaj.Sharma[@]rhul.ac.uk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The Bio-Repository of DNA in Stroke (BRAINS) recruits all subtypes of stroke as well as controls from two different continents, Europe and Asia. Subjects recruited from the United Kingdom (UK) will include stroke patients of European ancestry as well as British South Asians. Stroke subjects from South Asia will be recruited from India and Sri Lanka. Subjects are also recruited in Qatar. South Asian cases will also have control subjects recruited.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 7500
• Est. completion date: December 31, 2023
• Est. primary completion date: December 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Cases

Inclusion Criteria:

• Patients should be aged > 18 years at the time of enrolment.

• Diagnosis of haemorrhagic or ischemic stroke using World Health Organization guidelines confirmed by clinical examination and imaging (CT or MRI).

• All patients with cerebral arteriovascular malformations and aneurysms.

• South Asian or Caucasian ethnic backgrounds.

• Patient or relative written informed consent.

Exclusion Criteria:

• Unable to provide consent themselves or through surrogate.

• Stroke not defined on CT or MRI.

Controls

Inclusion Criteria:

• Patients should be aged > 18 years at the time of enrolment.

• No previous history of stroke.

• able to provide written consent.

Related Conditions & MeSH terms

• Hemorrhagic Stroke
• Ischemic Stroke
• Stroke
• Stroke Hemorrhagic
• Stroke, Ischemic

Locations

Country	Name	City	State
United Kingdom	Imperial College London	London

Sponsors (1)

Lead Sponsor	Collaborator
Royal Holloway University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	DNA repository of highly phenotyped stroke patients		5 years
Primary	Identify novel gene loci associated with different types of stroke		5 years