| Eligibility |
Inclusion Criteria:
1. Histologically confirmed Soft Tissue Sarcoma(STS) progression to 1 or 2 (less than 3)
prior chemotherapy
: Exclude pazopanib-resistant subtype - embryonal rhabdomyosarcoma, chondrosarcoma,
osteosarcoma, Ewing tumours, primitive neuroectodermal tumour, gastrointestinal
stromal tumour, dermatofibrosarcoma protuberans, inflammatory myofibroblastic sarcoma,
and liposarcoma
2. Age > 19 years at time of study entry.
3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (within 7 days
before screening)
4. Measurable disease by Response Evaluation Criteria in Solid Tumors Version 1.1
5. Adequate normal organ and marrow function as defined below
- Hemoglobin =9.0 g/dL
- Absolute neutrophil count (ANC) = 1500 per mm3
- Platelet count = 100,000 per mm3
- Serum bilirubin =1.5 x institutional upper limit of normal (ULN).
- Aspartate Aminotransferase (AST, SGOT)/Alanine Aminotransferase (ALT, SGPT) =2.5
x institutional upper limit of normal unless liver metastases are present, in
which case it must be =5x ULN
- Creatinine=1.5 x ULN or Measured or calculated(CrCl should be calculated per
institutional standard) creatinine clearance(GFR can also be used in place of
creatinine or CrCl) = 1.5 x institutional ULN
- International normalized ratio (INR) OR prothrombin time (PT) and activated
partial thromboplastin time (aPTT) : =1.5 × ULN unless participant is receiving
anticoagulant therapy as long as PT or aPTT is within therapeutic range of
intended use of anticoagulants
6. The participant (or legally acceptable representative if applicable) provides written
informed consent for the trial.
7. A male or female participant must agree to use a contraception as detailed in Appendix
2 of this protocol during the treatment period and for at least 120 days after the
last dose of study treatment and refrain from donating sperm during this period.
8. A female participant is eligible to participate if she is not pregnant, not
breastfeeding, and at least one of the following conditions applies:
1. Not a woman of childbearing potential (WOCBP) as defined in Appendix 2 OR
2. A WOCBP who agrees to follow the contraceptive guidance in Appendix 2 during the
treatment period and for at least 120 days after the last dose of study
treatment.
9. Archival tumor tissue sample or newly obtained [core, incisional or excisional] biopsy
of a tumor lesion not previously irradiated has been provided. Formalin-fixed,
paraffin embedded (FFPE) tissue blocks are preferred to slides. Newly obtained
biopsies are preferred to archived tissue.
Exclusion Criteria:
1. Receipt of the last dose of anticancer therapy (chemotherapy, immunotherapy, endocrine
therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal
antibodies, other investigational agent) 28 days prior to the first dose of study drug
2. Any previous treatment with a Programmed Death-1(PD1) or Programmed
Death-Ligand1(PD-L1) inhibitor, anti-PD-L2 agent, stimulatory/co-inhibitory T-cell
receptor (eg. CTLA-4, OX-40, CD137), and/or pazopanib
3. Any unresolved toxicity NCI CTCAE Grade =2 from previous anticancer therapy with the
exception of alopecia, vitiligo, and the laboratory values defined in the inclusion
criteria
4. Major surgical procedure (as defined by the Investigator) within 28 days prior to the
first dose of Investigational Product(IP).
5. Is currently participating in or has participated in a study of an investigational
agent or has used an investigational device within 4 weeks prior to the first dose of
study intervention.
6. A WOCBP who has a positive urine pregnancy test within 72 hours prior to
randomization. If the urine test is positive or cannot be confirmed as negative, a
serum pregnancy test will be required.
7. Has received prior radiotherapy within 2 weeks of start of study intervention.
Participants must have recovered from all radiation-related toxicities, not require
corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted
for palliative radiation (=2 weeks of radiotherapy) to non-Central Nervous System(CNS)
disease.
8. Has received a live vaccine or live-attenuated vaccine within 30 days before the first
dose of study intervention. Administration of killed vaccines is allowed.
9. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to the first dose of study drug.
10. Known additional malignancy that is progressing or has required active treatment
within the past 3 years. Note: Participants with basal cell carcinoma of the skin,
squamous cell carcinoma of the skin, urothelial cancer, or carcinoma in situ that have
undergone potentially curative therapy are not excluded.
11. Has known active Central Nervous System (CNS) metastases and/or carcinomatous
meningitis. Participants with previously treated brain metastases may participate
provided they are radiologically stable: without evidence of progression for at least
4 weeks by repeat imaging (note that the repeat imaging should be performed during
study screening), clinically stable and without requirement of steroid treatment for
at least 14 days prior to first dose of study intervention).
12. Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment and is allowed.
13. Has a history of or current(non-infectious) pneumonitis/interstitial lung disease that
required steroids
14. Has a known history of Human Immunodeficiency Virus (HIV) infection. Note: No HIV
testing is required unless mandated by local health authority.
15. Concurrent active Hepatitis B (defined as HBsAg positive and/or detectable HBV DNA)
and Hepatitis C virus (defined as anti-HCV Ab positive and detectable HCV RNA)
infection.
- Note: Hepatitis B and C screening tests are not required unless:
- Known history of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infection
- As mandated by local health authority
16. Known active infection requiring systemic therapy.
- Active infection including tuberculosis
- Active hepatitis B (HBsAg reactive and HBV DNA is detected)
- Active hepatitis C (anti-HCV reactive and HCV RNA [qualitative] is detected)
- Human immunodeficiency virus infection
17. Is pregnant or breastfeeding or expecting to conceive or father children within the
projected duration of the study, starting with the screening visit through 120 days
after the last dose of trial treatment.
18. Known allergy or hypersensitivity to any of the study drugs or any of the study drug
excipients.
19. Has had an allogenic tissue/solid organ transplant.
20. Has a history or current evidence of any condition, therapy, or laboratory abnormality
or other circumstance that might confound the results of the study, interfere with the
participant's participation for the full duration of the study, such that it is not in
the best interest of the participant to participate, in the opinion of the treating
investigator.
21. Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial.
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