A Phase II Study of Apatinib in STS Patients

Clinical Trial Summary

Apatinib is a kind of innovative medicines approved by China Food and Drug Administration（CFDA）, which was researched by Jiangsu Hengrui Pharmaceutical Co., Ltd. Apatinib is a kinase inhibitor of receptor tyrosine with VEGFR2. The protocol is to explore Apatinib for the effectiveness of advanced soft tissue sarcoma and safety.

See also
Status	Clinical Trial	Phase
Recruiting	`NCT02910895` - A Platform of Patient Derived Xenografts (PDX) and 2D/3D Cell Cultures of Soft Tissue Sarcomas (STS)	N/A
Recruiting	`NCT05621668` - A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma	Phase 1
Active, not recruiting	`NCT04032964` - Dose Finding Study of L19TNF and Doxorubicin in Patients With STS	Phase 1
Active, not recruiting	`NCT04577014` - Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma	Phase 1/Phase 2
Completed	`NCT01650077` - Therapeutic Response of Patients With Soft Tissue Sarcoma According to CHOI Criteria
Withdrawn	`NCT04906876` - A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomas	Phase 2
Terminated	`NCT02890368` - Trial of Intratumoral Injections of TTI-621 in Subjects With Relapsed and Refractory Solid Tumors and Mycosis Fungoides	Phase 1
Terminated	`NCT02628535` - Safety Study of MGD009 in B7-H3-expressing Tumors	Phase 1
Completed	`NCT02204111` - Patient Directed Intervention to Improve the Quality of Life for Patients With Soft Tissue Sarcoma
Withdrawn	`NCT01663090` - Ferumoxytol-Enhanced MRI in Adult/Pedi Sarcomas	N/A
Completed	`NCT01440088` - A Trial of TH-302 in Combination With Doxorubicin Versus Doxorubicin Alone to Treat Patients With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma	Phase 3
Completed	`NCT01259375` - Amrubicin Chemotherapy as First Line in Metastatic or Unresectable Soft Tissue Sarcoma	Phase 2
Completed	`NCT01106872` - Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas	Phase 1
Recruiting	`NCT00753727` - Sunitinib and Radiation in Patients With Resectable Soft-tissue Sarcoma	Phase 1/Phase 2
Terminated	`NCT00755261` - Phase II Study of Doxorubicin and Avastin® in Sarcoma.	Phase 2
Completed	`NCT00580320` - Safety Study of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma	Phase 1
Completed	`NCT00611078` - Environmental Pollutants and the Risk of Soft Tissue Sarcoma: A Pilot Study	N/A
Completed	`NCT03452644` - US-Guided Biopsy in the Diagnosis of Musculoskeletal Soft-Tissue Tumors
Recruiting	`NCT05539677` - Biobank and Register of Patients With Agresive Tumors for Translational and Analytical Research
Terminated	`NCT03520959` - A Phase 3, Randomized, Double-blind, Placebo-controlled Study For Subjects With Locally-advanced Unresectable or Metastatic Synovial Sarcoma (V943-003, IMDZ-04-1702)	Phase 3

NCT number	NCT03064243
Study type	Interventional
Source	Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Contact
Status	Not yet recruiting
Phase	Phase 2
Start date	March 1, 2017
Completion date	September 1, 2018

A Phase II Study of Apatinib in STS Patients

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms