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LDCT Chest In Assessment Of Apparently Healthy Smokers

Smoking Clinical Trial

Official title:
Role Of LDCT Chest In Assessment Of Apparently Healthy Smokers

Clinical Trial Summary

To evaluate the effectiveness of LDCT screening in detecting early-stage lung cancers among smokers who do not have symptoms of lung disease.

Clinical Trial Description

Tobacco smoking is the leading preventable cause of death worldwide .Chronic Obstructive Pulmonary Disease (COPD), lung cancer, and cardiovascular disease will be responsible for the majority of deaths in the developed world in the coming decades . COPD is characterised by chronic airflow limitation caused by a combination of small airway inflammation and parenchymal destruction (emphysema) . Since computed tomography (CT) has been validated as a non-invasive technique capable of identifying areas of lung parenchyma with emphysema , several studies have identified a subgroup of apparently healthy smokers who have emphysema but no airway obstruction Furthermore, this subgroup has the highest risk of developing lung cancer among smokers .It has been proposed that systemic inflammation may play an important pathogenic role in carcinogenesis . We will conducted this cross sectional study between. current and former smokers without airway obstruction participating in a lung cancer screening study: a study group of smokers with emphysema on the CT, and a control group of smokers without emphysema. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06070922
Study type Observational
Source Assiut University
Contact Hend saleh, lecture
Phone 01098988712
Email hend.m.saleh@gmail.com
Status Not yet recruiting
Phase
Start date October 20, 2023
Completion date December 20, 2024
View Details
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