The Effect of Tobacco Products on Wound Healing

Smoking Clinical Trial

Official title: The Effect of Tobacco Products on Wound Healing

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study is to evaluate the effect of various tobacco products (including but not limited to combustible cigarettes, medicinal nicotine, electronic cigarettes, and smokeless tobacco) on cutaneous wound healing. There will also be a non- smoking control group. This study will be designed as a pilot study. The majority of individuals will be recruited from ongoing studies at the University of Minnesota - Tobacco Research Programs.

Clinical Trial Description

Participants will be recruited from ongoing studies will some recruitment of tobacco users and non-smoking controls outside of ongoing studies. In this prospective, cohort study of various tobacco users and non-smokers, a punch biopsy model of wound healing will be used to determine the effects of various tobacco products on inflammatory response and oxidative stress response to wounding:

1. Clinical wound inflammation as assessed by:

1. Thermography,

2. Clinical assessment,

3. Laser Doppler Technologies,

4. Transcutaneous oxygen assessment

2. Biological wound inflammation as assessed by:

1. Cytokine profiles,

2. Histology,

3. Genetic assessment,

4. Epigenetic evaluation

3. Systemic inflammation as assessed by:

1. Biomarkers,

2. Cell counts ;

Related Conditions & MeSH terms

• Smoking
• Tobacco Smoking
• Tobacco Use

• NCT number: NCT04870970
• Study type: Observational
• Source: University of Minnesota
• Status: Active, not recruiting
• Start date: May 18, 2021
• Completion date: February 2027