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Signs and Symptoms clinical trials

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NCT ID: NCT00822328 Completed - Clinical trials for Signs and Symptoms, Digestive

Fermented Milk Drink on Human Intestinal Microflora

Start date: January 2009
Phase: Phase 2
Study type: Interventional

Fermented milk is a popular drink. Recent studies revealed that some fermented milk containing some strains of lactic acid bacteria have health-promoting effects through improvement of the intestinal microflora and modulation of the immune system. Lactobacillus casei strain Shirota (LcS) is a probiotic bacterium used in the production of fermented milk products and lactic acid bacteria preparations. LcS has been shown to modify allergen-induced immune responses in allergic rhinitis, altering fermentation patterns in the small bowel, prevention of recurrent urinary tract infections in women. Yakult®300 is a fermented milk containing at least 3x10^10 live LcS cells per 100 ml bottle. This study aimed to evaluate the effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human intestinal microflora.

NCT ID: NCT00799682 Completed - Dry Eye Disease Clinical Trials

Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z®

Start date: October 2008
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine if there is a difference in the ocular signs and symptoms of subjects' eyes using Xalatan® 0.005% versus Travatan Z® 0.004% based on the outcome of subject assessment and clinical assessment in patients with Ocular Hypertension or Glaucoma with mild to moderate dry eye at baseline in accordance with the Oxford Grading Scale.

NCT ID: NCT00799552 Completed - Dry Eye Syndrome Clinical Trials

Safety and Efficacy Study of RX-10045 on the Signs and Symptoms of Dry Eye

Start date: November 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of RX-10045 to placebo for the treatment of the signs and symptoms of dry eye.

NCT ID: NCT00784108 Completed - Skin Cancer Clinical Trials

Optimizing Photodynamic Therapy of Cutaneous Neoplastic Diseases Via Structured Illumination and Real-time Dosimetry.

Start date: October 2008
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate native tissue optical properties and photosensitizer optical properties in vivo with a novel, non-contact optical imaging device call Modulated Imaging to help optimize the laser exposure in future photodynamic treatment for patients with skin cancer. Photodynamic therapy involves the administration of a tumor-localizing photosensitizing agent that, when illuminated with the proper wavelength of light, can result in photochemical processes that cause irreversible damage to tumor tissues. Photodynamic therapy is non-invasive and has been shown to be effective in the treatment of skin cancer while producing excellent aesthetic appearance and psychological well-being in patients that normally would require invasive excisions.

NCT ID: NCT00754572 Completed - Clinical trials for Rheumatoid Arthritis

A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid Arthritis

Start date: February 2009
Phase: Phase 3
Study type: Interventional

This single arm, open-label study will assess the safety and efficacy with regar d to reduction of signs and symptoms of treatment with tocilizumab in combinatio n with methotrexate, in patients with moderate to severe active rheumatoid arthr itis. Patients will receive tocilizumab 8mg/kg iv, every 4 weeks and methotrexat e 10-25mg weekly. The anticipated time on study treatment is 3-12 months, and th e target sample size is <500 individuals.

NCT ID: NCT00723541 Completed - Breast Cancer Clinical Trials

Breast Lesion Analysis for Tomosynthesis Mammography

Start date: January 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to develop a computer-aided diagnosis system to find breast lesions, including masses and microcalcifications, which hopefully will improve breast cancer detection and classification.

NCT ID: NCT00718133 Completed - Allergy Clinical Trials

The Effect of Air Pollution on Lung Health Among Children Living in Haifa Bay Region, Israel

Start date: December 2008
Phase: N/A
Study type: Interventional

Haifa bay region is located close to a major industrial zone. The aim of the study is to evaluate the health status of children living in Haifa bay region. The health status will be evaluated using health questionnaires and spirometry.

NCT ID: NCT00717899 Completed - Allergy Clinical Trials

The Effect of Air Pollution on Lung Health Among School Children Living in Haifa Bay Region

Start date: December 2008
Phase: N/A
Study type: Interventional

Haifa bay region is located close to a major industrial zone. The aim of the study is to evaluate the health status of school children living in Haifa bay region.The health status will be evaluated using health questionnaires and spirometry.

NCT ID: NCT00652834 Completed - Clinical trials for Signs and Symptoms, Digestive

Small Bowel Capsule Endoscopy Findings in Patients Receiving Cellcept®

Start date: April 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study is to learn more about symptoms and gastrointestinal lesions associated with taking myfortic® by switching patients to a delayed release formulation that is developed to alleviate GI symptoms. A comparison of the frequency and severity of GI symptoms observed in patients treated with MMF (cellcept®) after conversion to myfortic® will be measured by using a self-assessed questionnaire called Gastrointestinal Symptom Rating Scale (GSRS). To prove the incidence and improvement of GI lesions in patients treated with MMF (cellcept®) after conversion to myfortic® will be measured by using Small Bowel Capsule Endoscopy (SBCE).

NCT ID: NCT00652808 Completed - Osteoarthritis Clinical Trials

Double-Blind, Double Dummy, Randomized Comparison Study to Evaluate the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Osteoarthritis of the Knee

Start date: May 2004
Phase: Phase 3
Study type: Interventional

This study was performed to demonstrate that treatment with valdecoxib 10 mg daily (QD) was at least as effective as with naproxen 500 mg twice daily (BID), a standard non-steroidal anti-inflammatory drug (NSAID), when taken for 6 weeks in Korean subjects with symptomatic osteoarthritis (OA) of the knee. Secondary objectives were to assess the overall safety and tolerability of valdecoxib 10 mg QD taken for 6 weeks in Korean subjects with symptomatic OA of the knee.