Diagnostic Utility of Exercise Cardiac Magnetic Resonance in the Assessment of Cardiac Dyspnea.

Shortness of Breath Clinical Trial

Official title:

Diagnostic Utility of Exercise Cardiac Magnetic Resonance in the Assessment of Cardiac Dyspnea.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03951779
• Other study ID #: 18-005354
• Status: Completed
• Phase: N/A
• Start date: December 14, 2018
• Est. completion date: January 10, 2020

Study information

• Verified date: March 2022
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Researchers are examining the diagnostic utility of an exercise cardiac MRI (eCMR) in the assessment of cardiac dyspnea (shortness of breath).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: January 10, 2020
• Est. primary completion date: January 10, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Consecutive patients aged =18 years years with suspected cardiac dyspnea who are scheduled to undergo right heart catheterization as dictated by a comprehensive examination and echocardiography will be included for enrollment.

Exclusion Criteria:

• Age <18 years

• Pregnancy

• Mechanical ventilation

• Acute or chronic renal failure (creatinine clearance <30 ml/min or requiring renal replacement therapy)

• Inability to perform MRI (i.e. claustrophobia, severe obesity (>150 kg), device incompatible with MRI)

• Inability to exercise

• Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial fibrillation with highly variable cycle lengths)

• Prior heart or lung transplantation

• Left ventricular systolic (ejection fraction <50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction)

• Significant left-sided valvular disease (=moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery

Related Conditions & MeSH terms

• Cardiac; Dyspnea
• Dyspnea
• Shortness of Breath

Intervention

Diagnostic Test:
• Exercise cardiac magnetic resonance imaging
Subjects will exercise on a treadmill and immediately following the completion of the stress protocol, subjects will undergo cardiac magnetic resonance imaging

Locations

Country	Name	City	State
United States	Mayo Clinic in Florida	Jacksonville	Florida

Sponsors (1)

Lead Sponsor	Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Ejection Fraction	Measured using exercise cardiac magnetic resonance imaging (eCMR) reported in percentages	Baseline
Primary	Stroke Volume	Measured using exercise cardiac magnetic resonance imaging (eCMG) reported in mL	Baseline
Primary	Longitudinal Strain Assessment	Measured using exercise cardiac magnetic resonance imaging (eCMG) reported in percentages	Baseline

External Links

•   Mayo Clinic Clinical Trials