Short Bowel Syndrome Clinical Trial
Official title:
Measurement of Body Composition by Air Displacement Plethysmography in Pediatric Intestinal Failure Patients
This study will determine if air-displacement plethysmography (ADP) provides accurate measurement of body composition (percent body fat and fat-free mass) in pediatric patients with intestinal failure, as compared to body composition measured by alternative standard methods, including deuterium dilution, bioimpedance analysis (BIA), dual x-ray absorptiometry (DXA) when clinically indicated, and routine anthropometric measurements.
Infants and children with intestinal failure (IF) require prolonged periods of parenteral
nutrition (PN) for sustenance and growth until intestinal adaptation allows adequate enteral
intake. Lean body mass (or muscle mass) preservation and accrual is an important goal during
this phase of nutritional rehabilitation. However, lean body mass is not accurately measured
by currently available anthropometric techniques. Thus, despite weight gain, muscle mass
depletion can remain undetected.
Little data exist in the field of measuring body composition in patients with intestinal
failure, where changes in body weight are commonly taken to indirectly measure
gastrointestinal absorptive function. Body composition analysis is of particular importance
in the management of these patients, since it can help guide medical, surgical and/or
nutrition interventions, including titration of enteral or parenteral nutrition. To the
investigators' knowledge there are no studies examining whether air-displacement
plethysmography (ADP) is a valid measure of body composition in patients with intestinal
failure.
The investigators propose a non-randomized, prospective cohort study to validate ADP as a
measure of body composition in infants and children with IF.
The investigators will apply non-radioactive (stable) isotope techniques to examine the
accuracy of ADP in measuring body composition in these children.
The investigators will also compare ADP with bioimpedance analysis and routine anthropometry.
Additionally, if subjects have had a recent dual-energy X- ray absorptiometry (DXA) scan, the
investigators will compare the ADP estimates of body composition to those obtained from DXA.
The investigators hypothesize that ADP is a feasible and accurate technique for body
composition measurements, and that the device can be used to serially measure lean body mass
and fat mass changes in this cohort. If the feasibility and accuracy of ADP for body
composition analysis can be demonstrated, the technique is likely to have wider applications
in other pediatric illnesses.
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