Sepsis Clinical Trial
Official title:
Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation
Change and predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring in Sepsis Patients With Successful Fluid Resuscitation
Fluid therapy for sepsis patients has always been a research hotspot. Early studies suggest
that early goal-directed therapy (EGDT) can reduce mortality in patients with sepsis and
septic shock, which is included in the guidelines. However, recent studies suggest that EGDT
does not reduce mortality. This may be related to the fact that EGDT only pays attention to
systemic circulation and neglects microcirculation.
In the past few decades, arterial blood pressure, blood lactic acid and other circulatory
indicators have been the target of septic shock treatment, but normal systemic circulation
does not mean normal tissue perfusion. Obstacles to tissue perfusion, oxygenation and
microcirculation may still exist. At the same time, compared with systemic hemodynamic
parameters, microcirculation parameters may play a stronger role in predicting the prognosis
of sepsis patients. It is believed that the ideal goal of resuscitation therapy for sepsis
should be based on whether microcirculation function has been restored or not.
Objective:to observe the success rate of microcirculation imaging and oxygen saturation of
peripheral tissues in sepsis patients under the guidance of current guidelines and
procedures. At the same time, we compared the predictive value of microcirculation indicators
to the prognosis of septic shock patients.
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