Testing Effect and Schizophrenia

Schizophrenia Clinical Trial

Official title:

Retrieval Practice in Patients With Schizophrenia : an Exploratory Study Using Word Pairs

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02150174
• Other study ID #: 5806
• Status: Completed
• Phase: N/A
• First received: May 26, 2014
• Last updated: October 4, 2017
• Start date: July 2014
• Est. completion date: August 2015

Study information

• Verified date: September 2017
• Source: University Hospital, Strasbourg, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

When people are tested on a previously learned material, they will latter remember it better even when compared to a condition where they can re-study it. This phenomenon is called retrieval practice and is supported by an extensive research literature mostly carried out in normal students. This paradigm begins to be used in cognitive remediation programs in patients suffering from memory difficulties.

The objective of this study is to investigate whether retrieval practice is spared in patients with schizophrenia.

If effective, this method could be used in cognitive remediation programs.

Since episodic memory difficulties are supposed to be secondary to deficits in the initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that retrieval practice is spared in schizophrenia

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: August 2015
• Est. primary completion date: August 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• French is the native language, or acquired before 5 years old

• People must be able to understand and follow the trial instructions

Specific inclusion criteria (for patients) :

• Diagnostic of schizophrenia, according to the DSM -5, clinically stable

• The treatment must remain unchanged during the trial

Exclusion Criteria:

• Severe or acute cerebral disease

• Other actual psychiatric disorder

• Use of drugs with high anticholinergic effect

• Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)

• Inappropriate use of drugs

Specific exclusion criteria (for healthy subjects) :

• Diagnostic of schizophrenia of a relative up to the third degree

Related Conditions & MeSH terms

• Episodic Memory Deficits
• Memory Disorders
• Schizophrenia

Intervention

Behavioral:
• Retrieval practice effect using word pairs and cued recall tests with feedback
In the first phase (encoding), people study a list of 48 word pairs non semantically associated. Then (initial test), they recall half of word pairs or restudy the other half. In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.

Locations

Country	Name	City	State
France	Centre Psychothérapique de Nancy	Laxou Cedex
France	Service de psychiatrie - Hôpital Civil - CHRU Strasbourg	Strasbourg

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of word pairs properly recalled	- The aim is to investigate the retrieval practice effect using word pairs and cued recall tests with feedback in patients with schizophrenia and healthy controls.; In the first phase (encoding), people study a list of 48 word pairs non semantically associated, then half of the pairs are presented in its completed form for two times, and for the other half the two subsequent re-exposure trials are framed as cued recall tests (the first word is presented and the subject has to remember and give orally the second word, and a feedback is given).; In the second phase (final test) which takes place 2 days later, all the 48 word pairs are presented as a cued recall test.; - We will compare in patients with schizophrenia and healthy controls final performance recall for information studied and recalled ("test" condition) to those for information studied and then re-studied ("re-study" condition).	Final test : 2 days after the first experimental session
Secondary	Difference between final performance recall and memory span score	In each group (patients with schizophrenia and healthy controls) : Difference between the final performance recall (see primary outcome measure) in "test" condition and "re-study" condition AND memory span score.	Final test : 2 days after the first experimental session