Schizophrenia Clinical Trial
Official title:
D-Serine Augmentation of Cognitive Retraining in Schizophrenia
This study will examine the effectiveness of D-serine in increasing and sustaining the benefits of cognitive retraining in people with schizophrenia.
This study is based on the hypothesis that by increasing NMDA receptor function in the brain
and thereby increasing the capacity of the brain to both form new connections and strengthen
existing connections, schizophrenic patients may derive both greater and sustained benefit
from cognitive retraining.
Patients with schizophrenia or schizoaffective disorder who are currently receiving
antipsychotic medication will be randomly assigned in a double-blind manner to receive
either D-serine (30 mg/kg) or placebo in addition to cognitive rehabilitation or a
non-interactive placebo for 12 weeks.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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