Sarcopenia — Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men
Citation(s)
Bross R, Ball RO, Pencharz PB Development of a minimally invasive protocol for the determination of phenylalanine and lysine kinetics in humans during the fed state. J Nutr. 1998 Nov;128(11):1913-9.
Campbell WW, Trappe TA, Wolfe RR, Evans WJ The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci. 2001 Jun;56(6):M373-80.
Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr. 2012 Dec;96(6):1454-64. doi: 10.3945/ajcn.112.037556. Epub 2012 Nov 7. Review.
Humayun MA, Elango R, Ball RO, Pencharz PB Reevaluation of the protein requirement in young men with the indicator amino acid oxidation technique. Am J Clin Nutr. 2007 Oct;86(4):995-1002.
Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E381-7. Epub 2006 Feb 28.
Kim JS, Wilson JM, Lee SR Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants. J Nutr Biochem. 2010 Jan;21(1):1-13. doi: 10.1016/j.jnutbio.2009.06.014. Epub 2009 Oct 1. Review.
Layman DK, Walker DA Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006 Jan;136(1 Suppl):319S-23S. Review.
Lemon PW Beyond the zone: protein needs of active individuals. J Am Coll Nutr. 2000 Oct;19(5 Suppl):513S-521S. Review.
Norton LE, Layman DK Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. J Nutr. 2006 Feb;136(2):533S-537S.
Pencharz PB, Ball RO Different approaches to define individual amino acid requirements. Annu Rev Nutr. 2003;23:101-16. Epub 2003 Feb 21. Review.
Riazi R, Wykes LJ, Ball RO, Pencharz PB The total branched-chain amino acid requirement in young healthy adult men determined by indicator amino acid oxidation by use of L-[1-13C]phenylalanine. J Nutr. 2003 May;133(5):1383-9.
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