A Study of Pazopanib and Durvalumab for Metastatic Soft Tissue Sarcoma

Sarcoma Clinical Trial

Official title:

A Phase II Trial of Pazopanib and Durvalumab for Metastatic Soft Tissue Sarcoma

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03798106
• Other study ID #: 4-2018-0743
• Status: Completed
• Phase: Phase 2
• Start date: April 10, 2019
• Est. completion date: August 10, 2022

Study information

• Verified date: June 2023
• Source: Yonsei University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Pazopanib is an angiogenesis inhibitor targeting VEGFR-1, -2, and -3; PDGFR-α and -β; and the receptor c-Kit, and is indicated for the treatment of subjects with advanced renal cell carcinoma (RCC) and advanced STS. For this orphan tumor, STS, PD-L1 targeting may be a promising strategy and favorable toxicity may warrant further combination.

Description:

Pazopanib is an angiogenesis inhibitor targeting VEGFR-1, -2, and -3; PDGFR-α and -β; and the receptor c-Kit, and is indicated for the treatment of subjects with advanced renal cell carcinoma (RCC) and advanced STS. Pro-angiogenic factors suppress various immune functions whereas antiangiogenic agents have potential to modulate the tumor microenvironment and improve immunotherapy. An analysis of patients with RCC treated with pazopanib demonstrated that elevated expression of PD-L1 correlates with shorter PFS. Investigator also identified 43% of PD-L1 expression in STS and PD-L1 expression had worse overall survival (5-year survival rate: 48% in PD-L1 positive vs. 68% in PD-L1 negative, p=0.015). In detail, PD-L1 expression was reported 52.6% in synovial sarcoma, 37.6% in rhabdomyosarcoma, and 100% in epithelioid sarcoma. For this orphan tumor, STS, PD-L1 targeting may be a promising strategy and favorable toxicity may warrant further combination.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: August 10, 2022
• Est. primary completion date: August 10, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

1. Histologically confirmed STS progression to 1 or 2 prior chemotherapy

2. Age > 18 years at time of study entry.

3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

4. Measurable disease by Response Evaluation Criteria in Solid Tumors Version 1.1

5. Body weight >30kg

6. Adequate laboratory findings

7. Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients.

8. Patient is willing and able to comply with the protocol for the duration of the study

9. Must have a life expectancy of at least 12 weeks

10. Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

11. Patients with evidence of portal hypertension (including splenomegaly detected radiographically) or any prior history of variceal bleeding must have had endoscopic evaluation within the 3 months immediately prior to enrollment, and the findings do not represent a high bleeding risk.

Exclusion Criteria:

1. More than 4 prior cytotoxic regimens

2. Participation in another clinical study with an investigational product during the last 2 weeks

3. Receipt of the last dose of anticancer therapy 14 days prior to the first dose of study drug

4. Any previous treatment with a PD1 or PD-L1 inhibitor (including durvalumab) and/or pazopanib

5. Mean QT interval corrected for heart rate (QTc) >480 ms calculated from 3 electrocardiograms (ECGs) using Fridericia's Correction

6. Any unresolved toxicity NCI CTCAE Grade =2 from previous anticancer therapy with the exception of alopecia, vitiligo, and the laboratory values defined in the inclusion criteria

7. Any concurrent chemotherapy, biologic, or hormonal therapy for cancer treatment within 2 weeks prior to entering the study. Concurrent use of hormonal therapy for non-cancer-related conditions (e.g., hormone replacement therapy) is acceptable

8. Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 4 weeks of the first dose of study drug

9. Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of IP.

10. History of allogenic organ transplantation.

11. Active or prior documented autoimmune or inflammatory disorders

12. Uncontrolled intercurrent illness

13. History of active infection

14. History of another primary malignancy

15. History of leptomeningeal carcinomatosis who are neurologically unstable or have required active treatment

16. Receipt of live attenuated vaccine within 30 days prior to the first dose of investigational product(IP).

17. Female patients who are pregnant or breastfeeding or male or female patients of reproductive potential who are not willing to employ effective birth control from screening to 90 days after the last dose.

18. Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients.

19. No history of any of the following in the past 6 months: cardiac angioplasty or stenting, myocardial infarction, unstable angina, coronary artery bypass graft surgery, symptomatic peripheral vascular disease class III or IV congestive heart failure, as defined by the New York Heart Association), thromboembolic events

Related Conditions & MeSH terms

• Sarcoma

Intervention

Drug:
• Durvalumab, pazopanib
Durvalumab 1500mg IV 1hr q3weeks Pazopanib 800mg QD PO q3wwks

Locations

Country	Name	City	State
Korea, Republic of	Severance Hospital, Yonsei University Health System	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Yonsei University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Objective Response Rate	antitumor efficacy of durvalumab and pazopanib	12 weeks