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Rupture clinical trials

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NCT ID: NCT03976063 Recruiting - Clinical trials for Preterm Premature Rupture of Membrane

Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation

TOCOPROM
Start date: October 7, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess whether short-term (48 hr) tocolysis reduces perinatal morti-morbidity in cases of PPROM at 22 to 33 completed weeks' gestation.

NCT ID: NCT03950024 Recruiting - Clinical trials for Anterior Cruciate Ligament Rupture

Improvement of Knowledge About the Arthrogenic Muscle Inhibition in the Aftermath of Knee Trauma.

CAMIK
Start date: October 29, 2019
Phase: N/A
Study type: Interventional

Arthrogenic Muscle Inhibition (AMI) is one of the classic complications occurring in the aftermath of knee trauma; AMI is grossly defined as a lack of extension due to quadriceps inhibition and hamstring contracture. However, its origins remains unknown with a strong suspicion for a central brain origin. It could be the missing link explaining this lack of extension following an anterior cruciate ligament (ACL) rupture. The primary hypothesis of this study is that a difference in activation of motor brain areas exists in patients with an ACL rupture, between those with AMI or without. The second hypothesis is that this difference could be seen on brain functional MRI.

NCT ID: NCT03913611 Recruiting - Rotator Cuff Tear Clinical Trials

Shoulder Surgery Traditional vs Accelerated Rehabilitation Trial

S-START
Start date: October 18, 2019
Phase: N/A
Study type: Interventional

This is a randomised controlled trial involving patients who have a double-row arthroscopic rotator cuff repair. Null hypothesis: There is no difference in outcome between standard rehabilitation and accelerated rehabilitation after arthroscopic rotator cuff repair. Following surgery, they will be randomised to one of two groups: 1. Standard rehabilitation, with enforced sling use for 6 weeks and a structured exercise programme. 2. Accelerated rehabilitation with no requirement to use a sling and a structured exercise programme. The primary outcome measure will be the Oxford Shoulder Score at 6 months. We will also collect data on postoperative pain, range of shoulder movement and other subjective outcome measures. All patients will have MRI scans at 6 months postoperatively to assess the integrity of the repair, allowing comparison of failure rates between groups.

NCT ID: NCT03896464 Recruiting - Clinical trials for ACL - Anterior Cruciate Ligament Rupture

Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings

SQuASH
Start date: January 1, 2020
Phase: N/A
Study type: Interventional

To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied. The 2018 International Olympic Committee (IOC) Consensus Statement now outlines the quadriceps tendon as a possible autograft option. However, no Randomised Control Trial (RCT) has examined the efficacy of the quadriceps tendon autograft in primary paediatric ACL reconstruction compared to the historical "gold-standard" soft-tissue hamstring autograft in this population. In light of its evidence for favourable outcomes in the adult population, and the (albeit limited) evidence showing safety and promise in the paediatric population, clinical equipoise exists for assessing its impact on outcomes in paediatric patients at the index surgery. This trial aims to demonstrate feasibility of a global RCT that will evaluate the efficacy of soft-tissue quadriceps versus hamstring autograft tendons on re-operation, return to sport, and knee function among paediatric patients undergoing primary ACL reconstruction.

NCT ID: NCT03890848 Recruiting - Rehabilitation Clinical Trials

Evaluation of the Effects of Home-based Functional Exercise on Patients With ACL

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

This study will evaluate the effect of home-based functional exercise on patients with anterior cruciate ligament rupture reconstruction based on the health belief model. About 360 participants will be randomly allocated into two groups. One group will randomized to receive precautions and rehabilitation progress reminders and other news by optimized WeChat applet regularly, while the other group will randomized to receive the rehabilitation exercise guidance during routine discharge.

NCT ID: NCT03873077 Recruiting - Pain, Postoperative Clinical Trials

Effect of LIA on Postoperative Pain Following ACL Reconstruction

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

An anterior cruciate ligament (ACL) rupture is one of the most common sport injuries, which typically develops after a sudden knee torsion. Arthroscopic repair of the ACL is often required as a complete ACL tear can cause instability of the knee joint. During arthroscopic reconstruction the lower leg is reattached to the upper leg using part of the hamstring tendon (mm. gracilis and mm. semitendinosus). Optimal postoperative analgesia is necessary to allow a quick recovery. Intravenous analgesia during surgery is often associated with a number of side effects such as nausea, vomiting and muscle weakness and does not anesthetize the donor site of the hamstring tendon graft. Local infiltration of ropivacaine and lidocaine in the knee joint and at the donor site can be a valuable asset to control the postoperative pain. This study evaluates the effect of local infiltration analgesia (LIA) on the postoperative pain in the first month after an ACL reconstruction. Half of participants will only receive intravenous analgesia during surgery, the other half will receive intravenous analgesia and a LIA.

NCT ID: NCT03806348 Recruiting - Clinical trials for Wound; Perineal Rupture, Dehiscence

Early Resuturing Versus Expectant Management Following Perineal Wound Dehiscence Among Women Who Had a Vaginal Delivery

Start date: December 12, 2018
Phase: N/A
Study type: Interventional

Women who deliver their baby vaginally often suffer from a perineal wound. The wound is after being sutured sometimes dehisced after days up to a few weeks and this study will investigate whether it is better to resuture early or leave the rupture for secondary healing.

NCT ID: NCT03789903 Recruiting - Clinical trials for Rupture of Membranes; Premature

Amniotic Fluid Lactate in Perterm Premature Rupture of Membranes

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

AF lactate level could help in predicting the duration from ROM till delivery

NCT ID: NCT03744078 Recruiting - Clinical trials for Induction of Labor Affected Fetus / Newborn

A Randomized Trial of Induction Methods in Premature Rupture of Membranes

Start date: April 15, 2018
Phase: N/A
Study type: Interventional

This study evaluates the addition of transcervical Foley catheter balloon and vaginal prostaglandin E2 induction in premature rupture of membranes. Half of participants will be used combine transcervical Foley catheter balloon and vaginal prostaglandin E2, while the other half will be used alone vaginal prostaglandin E2.

NCT ID: NCT03740022 Recruiting - Clinical trials for Anterior Cruciate Ligament Injury

ACL Versus ALL + ACL Study

Start date: November 2016
Phase: N/A
Study type: Interventional

The aim of the study is to show a reduction of a re-rupture rate with an ACL (antero crusader ligament) + ALL (anterolateral ligament) combined technique compared to a classical Kenneth-Jones ACL (antero crusader ligament) reconstruction technique.