Rheumatoid Arthritis Clinical Trial
Official title:
Biomarkers in Patients Suffering From Rheumatoid Arthritis Treated With Anti-interleukin-6 Therapy: a Prospective Monocentric Controlled Study
The use of anti-interleukin (IL)-6 therapy, including tocilizumab, in rheumatoid arthritis or
giant cell arteritis, led to the improvement or even control of disease in some patients for
whom no further therapeutic options were available. Nevertheless, the evaluation of the
efficacy of these treatments are negatively impacted by the lack of reliable biomarkers.
Indeed, usual inflammatory biomarkers used during the follow-up of these patients to detect
persistent disease activity or intercurrent infection, such as C-reactive protein, fibrinogen
and procalcitonin, are dependant on IL-6. Thse usual biomarkers cannot therefore be reliably
used during anti-IL-6 therapy. Some other experimental biomarkers are totally or partially
independent of IL-6, or even of inflammasome, and thus are credible candidates for the
follow-up of patients treated with anti-IL-6 therapy.
Here investigators propose a controlled, prospective, monocentric, observational study
evaluating several biomarkers, usual and experimental, in patients suffering from rheumatoid
arthritis treated with anti-IL-6 therapy.
This study will include 25 patients suffering from rheumatoid arthritis requiring an
anti-IL-6 therapy and 25 healthy controls.
In patients suffering from rheumatoid arthritis, usual and experimental biomarkers will be
assessed at D0, D15, W24 and W52 from the introduction of anti-IL-6 therapy, or during an
intercurrent infection.
Investigators thus hypothesized that experimental biomarker levels will still be increased at
D15, contrary to usual biomarkers dependant on IL-6 which will be normal whereas rheumatoid
arthritis is still active based on usual radiological and clinical criteria, and that all
biomarkers will be normal a W24.
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