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NCT03841279 Clinical Trial

Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis

Rheumatoid Arthritis Clinical Trial

Official title:
Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT03841279
Other study ID # 18-005455
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date January 1, 2019
Est. completion date December 2025

Study information
Verified date April 2024
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

MRI has been shown to be helpful in identifying patients who present with undifferentiated inflammatory arthritis who will develop RA within a one year follow up period. The absence of other clinically apparent symptoms often causes delays in diagnosis of RA. The use of the MRI in conjunction with the physical examination has the potential to reduce diagnostic delay. Earlier diagnosis would allow for earlier treatment implementation for better patient outcomes.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 100
Est. completion date December 2025
Est. primary completion date April 8, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: = 18 years old Undifferentiated inflammatory arthritis suspected to be early RA (=1 joint with synovitis and =1 other tender joint) Symptom duration =1 year Exclusion Criteria: Unwillingness or inability to return to Mayo Clinic Rochester for research follow-up visits Current or previous use of DMARDS Taking =10 mg of prednisone a day Contraindications to contract enhanced MRI History of another definite autoimmune or inflammatory rheumatic disease History of psoriasis History of inflammatory bowel disease Unsuitably as deemed by the principal investigator

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• MRI
Magnetic resonance imaging (MRI) produces detailed images of the body's internal structures without relying on radiation. It is used to diagnose and also gauge efficacy of treatment.

Locations
Country Name City State
United States Mayo Clinic Rochester Minnesota

Sponsors (1)
Lead Sponsor Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Earlier Diagnosis of RA if MRI is utilized To determine if MRI is predictive of later development of RA in patients with undifferentiated inflammatory arthritis; patients with inflammatory arthritis who receive an MRI will have earlier initiation of treatment 1 year
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