Thyroid Hormones in Critically Ill Children — Thyroid  

Respiratory Failure Clinical Trial

Official title: Thyroid Hormone Deficiency in Critically Ill Children

Status Terminated

Clinical Trial Summary

Thyroid hormones are substances naturally made by the body and are important to many of your body's basic functions such as breathing and brain function. We are investigating whether or not these hormones are at lower levels in critically ill children which could lead to further health problems. We hope to get a better understanding of hormone levels and their effects on critically ill children to better help other children in the future.

Clinical Trial Description

We hypothesize that critically ill children that require vasoactive infusions and/or invasive mechanical ventilation have thyroid hormone alterations. We will measure TSH, tT3, fT3, rT3, tT4, fT4, adn tyrosine concentrations in critically ill children with hypotension and/or respiratory failure and correlate thyroid hormone alterations to severity of illness, intensity of therapeutic interventions, and associated morbidity and mortality by using clinical outcomes parameters. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Critical Illness
• Hypotension
• Respiratory Failure
• Respiratory Insufficiency

• NCT number: NCT00664079
• Study type: Observational
• Source: Children's Hospital of Philadelphia
• Status: Terminated
• Phase: N/A
• Start date: October 2005
• Completion date: December 2008