Clinical Trials Logo

Clinical Trial Summary

The opening and aeration of the lung is critical for a successful transition from fetal to neonatal life. Early nasal CPAP in the delivery room in spontaneously breathing premature babies with a gestational age of 30 weeks or less is a standard treatment approach since it reduces the need for invasive mechanical ventilation and surfactant therapy. In respiratory distress syndrome (RDS) management, providing optimal lung volumes in the very early period from the beginning of delivery room approaches probably augments the expected lung protective effect. Although the benefits of CPAP support are well known, standart CPAP pressures recommended in the guidelines may not meet the needs of individual babies. Maintaining lung patency in the delivery room is the main mechanism of action of CPAP and the requirement may vary individually depending on lung physiology. In this multicenter randomized controlled study, we aimed to compare the effects of CPAP therapy applied with a personalized open lung strategy (openCPAP), and standard CPAP therapy (standardCPAP) on oxygenation, respiratory support need and surfactant treatment requirement in preterm babies with RDS in the delivery room.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05031650
Study type Interventional
Source Dokuz Eylul University
Contact Nuray Duman, Prof.
Phone 90 4121220
Email [email protected]
Status Recruiting
Phase N/A
Start date July 1, 2019
Completion date August 1, 2022

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04296071 - Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Not yet recruiting NCT04470297 - Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19 Phase 2
Not yet recruiting NCT01184313 - Acute Lung Injury After Aortic Valve Surgery N/A
Not yet recruiting NCT03661502 - Effect of Variable Volume Ventilation on Lung Compliance N/A
Enrolling by invitation NCT04645316 - The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung N/A
Active, not recruiting NCT02299921 - Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
Recruiting NCT03581006 - Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Trial
Recruiting NCT04372953 - Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial). N/A
Recruiting NCT02444858 - Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Paraquat Poisoning Induced Lung Injury Phase 1/Phase 2
Completed NCT03924206 - Hazardous Surgical Smoke: Risk Assessment and Evaluation of a New Smoke Extractor System in the Surgical Unit
Withdrawn NCT01939067 - Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP Phase 1
Completed NCT03437499 - Adrenomedullin Changes After Sustained Inflation or Positive Pressure Ventilation at Birth N/A
Recruiting NCT04989439 - Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants
Not yet recruiting NCT04115501 - Intra-operative Fraction of Inspired Oxygen and Lung Injury in Coronary Artery Bypass Grafting Surgery N/A
Recruiting NCT04755478 - LUS to Assess Lung Injury After Lung Lobectomy
Recruiting NCT03019354 - The Effect of Using High-flow Nasal Oxygen-delivery System in Patients Under Intravenous General Anesthesia N/A
Completed NCT01601223 - Local Assessment of Ventilatory Management During General Anesthesia for Surgery N/A
Completed NCT03410511 - Propylene Glycol/Glycerol Intake and Cardiorespiratory Function N/A
Recruiting NCT04962542 - Ventilation During Cardiopulmonary Bypass N/A
Recruiting NCT03016182 - Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery N/A