Renal Cell Carcinoma Clinical Trial
Official title:
Contrast-Enhanced Ultrasound for the Evaluation of Renal Cell Carcinoma Cryoablation
This pilot clinical trial compares the imaging results of contrast-enhanced ultrasound to contrast-enhanced magnetic resonance imaging (MRI) or computed tomography (CT), the current clinical standard, in predicting treatment response in patients with kidney cancer undergoing cryosurgery (a procedure in which an extremely cold liquid or an instrument called a cryoprobe is used to freeze and destroy abnormal tissue). Using contrast-enhanced ultrasound that does not involve a dye may help patients avoid side effects from a dye that is usually used in MRI or CT and may help doctors measure blood flow and determine whether the cryosurgery procedure treated the kidney tumor.
PRIMARY OBJECTIVES:
I. Evaluate if contrast-enhanced ultrasound can be used to successfully evaluate the
cryoablation (cryosurgery) of renal cell carcinoma.
SECONDARY OBJECTIVES:
I. Establish whether contrast-enhanced ultrasound provides a reliable tool for the
characterization of renal masses prior to cryoablation.
TERTIARY OBJECTIVES:
I. Compare harmonic imaging (the current industry standard for contrast imaging) with
subharmonic imaging (a novel, improved contrast imaging technique) in the two aims listed
above.
OUTLINE:
Patients receive perflutren protein-type A microspheres intravenously (IV) and then undergo
contrast-enhanced ultrasound imaging the morning prior to cryosurgery and at 3-4 months post
treatment during MRI or CT follow up.
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