Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss

Status Recruiting

Clinical Trial Summary

Recurrent pregnancy loss (RPL) defined as 3 or more pregnancy losses affects approximately 3% of couples trying to achieve parenthood. Most cases of RPL are unexplained and have no effective treatment to improve the chance of a live birth. Exciting indications for using Hydroxychloroquine (HCQ) include: Malaria profylaxis and treatment, systemic and discoid lupus erythematosus (SLE) and rheumatoid athritis (RA). HCQ has been reported to have the following properties (anti-thrombotic, vascular-protective, immunomodulatory, improving glucose tolerance, lipid-lowering, and anti-infectious).

There is no data concerning the benefit of HCQ in RPL. Administration for other indications provides extensive safety data during pregnancy.

This study has the potential to establish support for a new treatment option for unexplained RPL.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03305263
Study type	Interventional
Source	Rigshospitalet, Denmark
Contact	Henriette Svarre Nielsen, MD, DMSc
Phone	+4535457515
Email	henriette.svarre.nielsen@regionh.dk
Status	Recruiting
Phase	Phase 3
Start date	January 25, 2018
Completion date	January 2023

View Details

See also
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