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Clinical Trial Summary

The purpose of this study is to determine whether adding deep hyperthermia to neoadjuvant concurrent radiochemotherapy could improve T-downstaging rate for locally advanced rectal cancer (LARC).


Clinical Trial Description

The purpose of this study is to determine whether adding deep hyperthermia to neoadjuvant concurrent radiochemotherapy could improve T-downstaging rate for locally advanced rectal cancer (LARC). The sample size is 142. Patients with LARC (T3-4/N+) will be randomly divided into intervention group and control group. For intervention group, the neoadjuvant therapy is hyperthermia combined with concurrent radiochemotherapy. For control group, the neoadjuvant treatment is concurrent radiochemotherapy. T-downstaging rate will be used to evaluate the effectiveness of deep hyperthermia. T-downstaging is defined as the postoperative pathological T stage lower than the original T stage by imaging before treatment. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05070832
Study type Interventional
Source Peking University Third Hospital
Contact Hao Wang, Doctor
Phone 82264911
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date January 1, 2022
Completion date December 31, 2024

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