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Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

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NCT ID: NCT00528944 Completed - Emphysema Clinical Trials

Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity

Start date: January 2006
Phase: N/A
Study type: Observational

Although single breath helium (He) dilution measurement (VASB) is currently used in pulmonary function laboratories to assess functional alveolar volume and diffusing capacity for carbon monoxide, the extent to which VASB reflects ventilatory and thoracic volume has not been prospectively determined in emphysema. We hypothesized that VASB underestimates rebreathe helium dilution volume (VARB), and plethysmographic volume (VApleth) as clinical and physiologic severity of emphysema increases.

NCT ID: NCT00517998 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study

Start date: May 2007
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of the Biologic Lung Volume Reduction System (BLVR) for patients with advanced emphysema refractory to medical therapy.

NCT ID: NCT00515164 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study

Start date: August 2007
Phase: Phase 2
Study type: Interventional

The purpose of this study it to evaluate the efficacy and safety of the 20 mL BLVR System in patients with advanced upper lobe predominant emphysema.

NCT ID: NCT00475007 Completed - COPD Clinical Trials

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema

IBV®Valve
Start date: September 2007
Phase: N/A
Study type: Interventional

This trial is for men and women between the ages of 40 and 74 who have a confirmed diagnosis of emphysema. The objective of the trial is to determine the safety and effectiveness of the IBV Valve at redirecting airflow from diseased portions of the lung to healthier areas to achieve improvement in disease-related health status.

NCT ID: NCT00435253 Completed - Pulmonary Emphysema Clinical Trials

US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study

Start date: February 2007
Phase: Phase 2
Study type: Interventional

Evaluate the efficacy and safety of the 10 mL BLVR System in 1 or 2 treatment sessions (8 subsegments, 4 in each lung) in patients with advanced upper lobe predominant emphysema.

NCT ID: NCT00413205 Completed - Emphysema Clinical Trials

TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)

Start date: January 2007
Phase: Phase 2
Study type: Interventional

This 2 arm study will investigate the efficacy, safety and tolerability of RAR Gamma versus placebo in ex-smokers with moderate or severe emphysema treated with optimal COPD therapy. Following optimization of COPD therapy (up to 6 weeks) patients will be randomized to receive either RAR Gamma (5mg) or placebo once daily using a 2:1 ratio (active:placebo), in addition to their standard therapy. Following the double-blind treatment period, patients will enter a 4-week follow-up period. The anticipated time on study period is 1-2 years, and the target sample size is 100-500 individuals.

NCT ID: NCT00347659 Completed - Pulmonary Emphysema Clinical Trials

US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study

Start date: June 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety of the Biologic Lung Volume Reduction System (BLVR) for patients with advanced emphysema.

NCT ID: NCT00269087 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)

Start date: January 28, 2005
Phase: Phase 3
Study type: Interventional

This study evaluates the safety of medicine on COPD (Chronic Obstructive Pulmonary Disease). This study will last up to 56 weeks, and subjects will visit the clinic 16 times. Subjects will be given breathing tests, and will record their breathing symptoms daily on diary cards.

NCT ID: NCT00261833 Completed - Emphysema Clinical Trials

Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency

Start date: March 2006
Phase: Phase 4
Study type: Interventional

This is a randomized, placebo-controlled, double-blind, multicenter phase III/IV study to compare the efficacy and safety of Zemaira® with placebo in subjects with emphysema due to alpha1-proteinase inhibitor deficiency. The effect of Zemaira® on the progression of emphysema will be assessed by the decline of lung density, measured by computed tomography (CT).

NCT ID: NCT00207337 Completed - Emphysema Clinical Trials

Exhale (R) Stent for Emphysema

Start date: July 2004
Phase: Phase 2/Phase 3
Study type: Interventional

Current treatment for emphysema is limited to measures that include inhaled oxygen, bronchodilators, anti-inflammatory drugs and pulmonary rehabilitation. Highly invasive procedures such as lung volume reduction surgery or lung transplantation are also performed. Treatment using the Exhale Drug-Eluting Stent (DES) is a minimally invasive bronchoscopic treatment that has the potential to reduce shortness of breath in emphysema patients. This study tests the safety and effects of Exhale DES in the treatment of patients with emphysema.