D-dimer Testing Tailored to Clinical Pretest Probability in Suspected

Status Completed

Clinical Trial Summary

Prospective, multicentre, cohort study assessing a diagnostic management strategy for suspected Pulmonary Embolism with independent central adjudication of outcomes

Clinical Trial Description

This is a prospective, multi-centre, cohort study that will assess a new diagnostic management strategy for suspected Pulmonary Embolism (inpatients and outpatients). The new diagnostic strategy is designed to reduce the use of imaging tests for Pulmonary Embolism, particularly Computed Tomography Pulmonary Angiogram, by excluding Pulmonary Embolism with combinations of Clinical Pretest Probability and D-dimer results in a higher proportion of patients. The safety of this management strategy will be established by demonstrating a very low rate of proximal Deep Vein Thrombosis or Pulmonary Embolism during 90 days of follow-up in patients who had anticoagulant therapy withheld in response to negative diagnostic testing. Diagnostic test utilization will be assessed. All clinical outcomes will be adjudicated by a central independent adjudication committee that will be blind to initial D-dimer measurements and patient management. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02483442
Study type	Observational
Source	McMaster University
Contact
Status	Completed
Phase
Start date	December 11, 2015
Completion date	September 24, 2019

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D-dimer Testing Tailored to Clinical Pretest Probability in Suspected Pulmonary Embolism — PEGeD

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms