Bennion MR, Hardy G, Moore RK, Millings A E-therapies in England for stress, anxiety or depression: what is being used in the NHS? A survey of mental health services. BMJ Open. 2017 Jan 23;7(1):e014844. doi: 10.1136/bmjopen-2016-014844.
Carey, T (2006). The method of levels : how to do psychotherapy without getting in the way. Living Control Systems Pub.
Carey, T a., & Mullan, R. J. (2008). Evaluating the method of levels. Counselling Psychology Quarterly, 21(October 2014), 247-256. https://doi.org/10.1080/09515070802396012
Cocklin AA, Mansell W, Emsley R, McEvoy P, Preston C, Comiskey J, Tai S Client Perceptions of Helpfulness in Therapy: a Novel Video-Rating Methodology for Examining Process Variables at Brief Intervals During a Single Session. Behav Cogn Psychother. 2017 Nov;45(6):647-660. doi: 10.1017/S1352465817000273. Epub 2017 May 22.
Duarte A, Walker S, Littlewood E, Brabyn S, Hewitt C, Gilbody S, Palmer S Cost-effectiveness of computerized cognitive-behavioural therapy for the treatment of depression in primary care: findings from the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial. Psychol Med. 2017 Jul;47(10):1825-1835. doi: 10.1017/S0033291717000289. Epub 2017 Feb 23.
Gaffney H, Mansell W, Edwards R, Wright J Manage Your Life Online (MYLO): a pilot trial of a conversational computer-based intervention for problem solving in a student sample. Behav Cogn Psychother. 2014 Nov;42(6):731-46. doi: 10.1017/S135246581300060X. Epub 2013 Jul 30.
Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease.
Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods.
Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial.
Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.
Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.
