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Clinical Trial Summary

This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living cells. Collecting blood in order to study metabolites may help doctors monitor and treat prostate cancer more effectively.


Clinical Trial Description

PRIMARY OBJECTIVES: I. Develop blood sample collection and preparation procedures for reliable, meaningful metabolomic profiling of peripheral blood mononuclear cells (PBMCs) by liquid chromatography/quadruple-time of flight/mass spectrometry (LC/Q-TOF/MS) that can be implemented in a clinical setting. II. Optimize data analysis methods and software usage to create a metabolic profile for patients at the time of blood collection. III. Compare metabolite profiles of isolated PBMCs versus (vs.) other blood fractions (plasma, red blood cells [RBCs], and whole blood). IV. Identify elements of the PBMC metabolite profile that may correlate to patient disease state. OUTLINE: Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03485794
Study type Observational
Source University of Southern California
Contact Brandi Scott
Phone 310-272-7653
Email Brandi.Scott@med.usc.edu
Status Recruiting
Phase
Start date November 14, 2017
Completion date November 14, 2026

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