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Prolapse clinical trials

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NCT ID: NCT03832543 Completed - Clinical trials for Vault Prolapse, Vaginal

Modified Uterosacral Ligament Suspension in Vaginal Hysterectomy

Start date: April 1, 2016
Phase:
Study type: Observational

Introduction : The extraperitoneal uterosacral ligament suspension (ULS) can be performed during the removal of the uterus in vaginal hysterectomy to prevent cuff prolapse. In this study, the modified extraperitoneal ULS technique was evaluated in terms of preventing cuff prolapse. Methods / Technique : Forty patients with second and third-stage uterine prolapse who were operated were included in the study. During routine vaginal hysterectomy procedure performed on patients, after sacrouterine ligaments which are the first-bites and uteroovarian and round ligaments which are the last-bites have been sutured and knotted, these ligaments were marked with 4-distinct clemps to make the right and left, upper and lower separation. After vaginal cuff was closed the sutures hanged by the clamps were ligated together, and the cuff tissue was stretched to the apical line.

NCT ID: NCT03820089 Completed - Prolapse Clinical Trials

Evaluation of TP US in Women With Prolapse

Start date: January 29, 2019
Phase:
Study type: Observational [Patient Registry]

Many women suffers from uterine and vaginal prolapse Usually they suffer from these symotoms in menopause

NCT ID: NCT03818321 Completed - Clinical trials for Pelvic Organ Prolapse

Urinary Track Infection Prevention After Urogynecological Surgery

Start date: June 17, 2019
Phase: Phase 2
Study type: Interventional

This study is randomized double-blinded placebo-controlled trial to access oral Methenamine Hippurate (MH) in combination with cranberry capsules is superior to cranberry capsules alone in prevention of UTI in patients with transient post-operative urinary retention requiring a Foley catheter after pelvic reconstructive surgery.

NCT ID: NCT03809806 Completed - Clinical trials for Pelvic Organ Prolapse

Four-arm Mesh for Vaginal Stump Prolapse

Start date: January 1, 2014
Phase: N/A
Study type: Interventional

To estimate the safety and efficacy of performing modified anterior transvaginal mesh surgery using polypropylene mesh for treatment of advanced urogenital prolapse after hysterectomy (stage III and IV vc Pelvic Organ Prolapse Quantification [POP-Q] system staging).

NCT ID: NCT03779633 Completed - Clinical trials for Pelvic Organ Prolapse

Preoperative Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse

Start date: February 2, 2017
Phase: Phase 4
Study type: Interventional

Introduction With increasing age the incidence of pelvic organ prolapse (POP) rises and will increase substantially in the future according to forecasting studies. It is possible that oestrogens, alone or in combination with other forms of therapy, may assist in the management of POP by increasing collagen synthesis and thereby improving the strength of the weakened vaginal epithelium. Yet, studies investigating the effect of topical oestrogen and its impact on POP associated symptoms, both self-reported improvement and observations of objective improvement, are lacking. Objective To evaluate the subjective efficacy concerning prolapse associated complaints measured by the German pelvic floor questionnaire (domain POP: POP-score) after preoperative use of local oestrogen compared to preoperative placebo treatment in postmenopausal women with symptomatic pelvic organ prolapse. Further variables of interest are POP-score after 3 months, differences regarding the objective prolapse quantification system (POP-Q), surgical outcome and tissue operability assessed by the surgeon. Methods In this prospective, randomized, double-blind, placebo-controlled, multicenter study the investigators aim to include 120 postmenopausal women with symptomatic pelvic organ prolapse and indicated operative procedure. An analysis of covariance will be computed with the depending variable POP-score after 6 weeks and the independent variables group (verum versus placebo) and Pop-Score at baseline.

NCT ID: NCT03772691 Completed - Clinical trials for Pelvic Organ Prolapse

Lateral Suspension and Sacropexy for Pelvic Organ Prolapse

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Pelvic organ prolapse (POP) is considered one of the commonest gynecologic health problems all over the world. Pelvic organ prolapse (POP) is common and can be seen in up to 50% or more of parous women. The annual aggregated rate of associated surgery for pelvic organ prolapse is in the range of 10-30 per 10,000 women. It is estimated that women have an 11-19% life-time risk of undergoing surgery for POP. This rate is projected to increase over the next 2-3 decades. Apical POP refers any descent of the cervix or the vaginal cuff scar(as after hysterectomy) below a point which is 2 cm less than the total vaginal length about the plane of the hymen. Apical POP is due to defect in apical support with damage to the cardinal and uterosacral ligaments. Apical pelvic organ prolapse is a common issue in our country with significant incidence rate due to many predisposing factors including increasing age, higher gravidity and parity (especially the number of vaginal births)

NCT ID: NCT03772015 Completed - Prolapse Genital Clinical Trials

The Change in Vaginal Axis on MRI After Uterus Preserving Laparoscopic Lateral Mesh Suspension

Start date: December 9, 2018
Phase:
Study type: Observational

Laparoscopic lateral mesh suspension is emerged as a practical, safe and feasible alternative to sacropexy to treat female genital apical prolapse. Investigators hypothesized that uterus-preserving lateral suspension provides a better anatomical positioning.

NCT ID: NCT03764891 Completed - Clinical trials for Pelvic Organ Prolapse

Clinical Outcomes of Transvaginal Mesh Procedures for Cystocele Repair: Comparisons of Uphold and Perigee Systems

Start date: November 2, 2018
Phase:
Study type: Observational

Pelvic organ prolapse (POP) is a major health concern, affecting more than 30% of women. The aim of this study was to compare the clinical outcomes of Uphold system and Perigee system in treating women with cystocele.

NCT ID: NCT03730103 Completed - Clinical trials for Pelvic Organ Prolapse

Same Day Discharge After Minimally-invasive Sacrocolpopexy

Start date: October 22, 2018
Phase: N/A
Study type: Interventional

This is a prospective cohort study evaluating safety, cost and patient satisfaction with SDD for patients undergoing minimally invasive sacrocolpopexy for pelvic organ prolapse. A prospectively collected, historical control group who underwent the same surgical procedure will be utilized to compare these outcomes when applicable. SDD will be facilitated in part by a utilizing novel patient education video created for this study and implementing an ERAS pathway. All patients meeting eligibility criteria will be approached for study participation. Outcomes will be assessed on POD 0/1 and at the routine post-operative follow up visit, generally at 6 weeks after surgery.

NCT ID: NCT03722563 Completed - Clinical trials for Pelvic Organ Prolapse

Total Laparoscopic Hysterectomy With Sacrocolpopexy Versus Total Laparoscopic Hysterectomy With Lateral Suspension in Patients With Pelvic Organ Prolapse

Start date: January 8, 2019
Phase: N/A
Study type: Interventional

This prospective randomized surgical trial is designed to compare objective and subjective outcomes of total laparoscopic hysterectomy with sacrocolpopexy versus total laparoscopic hysterectomy with lateral suspension for the treatment of pelvic organ prolapse