Ovarian Cancer Clinical Trial
Official title:
A Phase II, Non-Randomized Study of Abraxane Plus Carboplatin in Patients With Recurrent Platinum-Sensitive Ovarian or Primary Peritoneal Cancer
The purpose of this study is to determine if the combination of Abraxane and Carboplatin together will improve the chances of controlling recurrent ovarian/fallopian tube/peritoneal cancer.
Current best practice recommends Carboplatin combined with Taxol in the treatment of Ovarian
cancer.
Taxol is paclitaxel in the solvent Cremophor-El and the solvent has been associated with
significant side effects e.g. anaphylaxis and hypersensitivity. this requires the routine
use of premedication with antihistamines and steroids.
Abraxane by contrast is Cremophor-El free and is protein bound. This has 2 advantages over
Taxol.
1. No need for routine premedications
2. Increased drug entry into cells facilitating greater potential for anti-tumor activity.
Schedule: Carboplatin day1 every 28days. Abraxane day1,8,15 every 28days.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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