Preterm Birth Clinical Trial
Official title:
The Effect of Prematurity and Hypertensive Disorders of Pregnancy on Offspring Cardiovascular Health
The purpose of this study is to investigate whether exposure to hypertensive disorders of pregnancy and/or a preterm birth results in alterations in the cardiovascular system during infancy.
While the incidence of cardiovascular disease has reduced dramatically, coinciding with
favourable changes in risk factors, cardiovascular disease remains the single largest cause
of mortality and premature mortality in the United Kingdom. Identification of novel
biological pathways that underlie disease susceptibility raises the potential for new early
primary prevention strategies to complement classical management. There is particular
interest in the role of early environment in 'programming' risk of cardiovascular disease in
later life and growing evidence that various early life exposures impact cardiovascular
health in the longer term.
The investigators have therefore designed the EPOCH study to investigate whether those
individuals born to hypertensive pregnancies and/or to a preterm birth demonstrate
differences in the cardiovascular phenotype at birth, or whether they develop any
differences over the first three months of life and whether this varies with other perinatal
factors. This study also allows investigation of the short term impact of perinatal
interventions used in this cohort. Comprehensive multi-modality non-invasive imaging
measures of cardiovascular structure and function allow precise quantification of
cardiovascular phenotype in this population.
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Observational Model: Case Control, Time Perspective: Prospective
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