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Testing Effects of Melatonin on Uterine Contractions in Women — MelPreg  

Pregnant Women Clinical Trial

Official title:
Testing Effects of Melatonin on Uterine Contractions in Women

Clinical Trial Summary

The study will extend recent discoveries that have been made in basic human physiology related to responses melatonin and uterine contractions in late- or full-term pregnant women. The basic physiology work has been conducted in in vitro models of the human myometrium characterizing its responses to melatonin, and in pilot in vivo studies correlating the number of uterine contractions with melatonin concentrations that were manipulated by different types of light exposure. The planned experiments will test a causal link between circulating melatonin levels and uterine contractions in full-term pregnant women by manipulating melatonin levels using exogenous melatonin (i) during the day when endogenous levels of melatonin are very low (Experiment 1), and (ii) during the evening under conditions with lighting that would be expected to suppress the higher evening and nighttime levels of endogenous melatonin (Experiment 2).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05358834
Study type Interventional
Source Brigham and Women's Hospital
Contact Elizabeth B Klerman, MD PhD
Phone 617-643-2424
Email ebklerman@hms.harvard.edu
Status Recruiting
Phase N/A
Start date January 1, 2023
Completion date June 30, 2027
View Details
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