Preeclampsia Clinical Trial
Official title:
Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia
Introduction: The etiology/pathophysiology of preeclampsia remains an enigma. Cellular
immunity is a key factor in the etiology of late-onset preeclampsia (L-PrE). Presepsin is
split out from the phagocytes membranes after phagocytosis. To investigators knowledge, this
is the first study in literature to investigate maternal blood concentrations of presepsin in
preeclampsia and healthy pregnant women.
Methods: The investigators examined maternal plasma interleukin-6, presepsin and pentraxin-3
concentrations in pregnant women with (n=44) and without L-PrE (n=44). These three
inflammatory markers concentrations measured using enzyme-linked immunosorbent assays were
compared.
This observational case-control study was designed at Cengiz Gokcek Women's and Children's Hospital, Gaziantep, Turkey, in the Department of Obstetrics and Gynecology between June 2018 and January 2019. The protocol was approved by the Ethics Committee for Clinical Research of Gaziantep University (Reference number: 2018/393). The study strictly adhered to the principles of the Declaration of Helsinki. All subjects included in the study gave oral and written informed consent. Eighty-eight women were enrolled in the study in two groups. All participants will gave their oral and written informed consent before their inclusion in the study. ;
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