Progesterone in Expectantly Managed Early-onset Preeclampsia

Status Completed

Clinical Trial Summary

Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks postpartum

Clinical Trial Description

Currently there is no effective treatment for early-onset preeclampsia except for early delivery of the fetus along with the placenta. Progesterone supplementation in the form of 17-alpha-hydroxyprogesterone caproate (17-OHPC) is currently used obstetrically to prevent recurrent preterm birth in patients with pregnancies not complicated by preeclampsia. Previous studies reported that patients with severe PE had significantly lower serum progesterone concentrations than gestational age- and race-matched non-preeclamptics. Moreover, supplementation of placental ischemic rats with 17-OHPC decreased blood pressure, inflammatory cytokines, and ET-1 within 24 hours of treatment ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04077853
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	Phase 4
Start date	December 15, 2019
Completion date	January 15, 2022

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